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筑波大学医学医療系血液内科学
坂田麻実子
坂田麻実子
2024年11月千葉滋教授の後任として筑波大学医学医療系血液内科学教授に着任しました坂田麻実子です。
当教室は、日本血液学会血液専門医18名を含むスタッフ・学生・専攻医によって、最先端の血液学研究、リサーチマインドをもった若手医師および研究者教育、高度医療を実践しております。
対象とする疾患は、悪性リンパ腫や白血病をはじめとする造血器腫瘍、溶血性貧血や凝固異常症をはじめとする非腫瘍性疾患まで、多岐にわたります。特に造血器腫瘍においては、化学療法や分子標的療法に加えて、近年急速に進展しているゲノム医療、HLA半合致移植および臍帯血移植等を含む造血幹細胞移植、キメラ抗原(CAR)-T細胞療法も取り入れ、最先端の専門的な医療を提供できる体制を整えております。
働き方改革や価値観が多様化する時代にこそ、変化に左右されることのない普遍的な目標が重要と考えます。当教室の目指す理念は以下の3つです。
1. 教室員が互いに切磋琢磨し、学問としての血液学を最高峰まで追求・発展させること
2. その成果を臨床へと還元し、患者さんの診療に役立つトランスレーショナルリサーチへと昇華させること
3. 患者さんの心に寄り添い、仲間との輪を大切にして、これらを成し遂げること
出身大学や国籍の垣根を超え、教室員の一人ひとりが「血液学を発展させる側に立つ」という心意気をもつことで、今日の患者さん、そして明日の患者さんに最善の医療を提供できるよう真摯に取り組んで参ります。
領域別特徴
造血器腫瘍
多数の急性骨髄性白血病、骨髄異形成症候群、急性リンパ性白血病、慢性骨髄性白血病、慢性リンパ性白血病、悪性リンパ腫、多発性骨髄腫などの造血器悪性腫瘍の患者さまを診察しております。白血病や悪性リンパ腫などの疾患の中には特異的な遺伝子変異の異常や融合遺伝子が診断や最適な治療法の選択の鍵となる場合があります。当院では多数の遺伝子検査を院内で実施することが可能です。これらの疾患には、世界的に標準的な治療法・治療基準があり原則として私たちもそれらの治療を行いますが、標準療法で救済しにくい患者さま方には、臨床試験への参加をお伺いすることがあります。
特発性造血障害
再生不良性貧血、発作性夜間血色素尿症、骨髄異形成症候群などの患者さまを診療しております。
再生不良性貧血の診断時に発作性夜間血色素尿症を除外するために、これまでの Ham試験、砂糖水試験に加え、フローサイトメトリーを用いた赤血球表面抗原検索を行い、診断精度の向上に努めております。
骨髄異形成症候群は、現在でも治療法が確立していない疾患ですが、造血幹細胞移植、免疫抑制療法など様々な治療を検討し、個々の患者さまに最も適した治療法を選択しております。
血小板・凝固異常症
a）特発性血小板減少性紫斑病
ITP：標準的治療、内視鏡による脾臓摘出、高齢者向けの治療法などで患者さまの治療に当たっております。特に難治性の患者さまの新しい治療法の検討を行っております。
b）血友病と類縁疾患・血栓性疾患
現在血友病A、Bの他、第5、12、13因子欠乏の方の診療にあたっています。抗凝固因子による後天性凝固因子欠乏の診断も速やかに研究室で行うことができます。
その他の疾患
上記以外にも、多血症・骨髄線維症・本態性血小板増加症、白血球・赤血球・血小板の増加・減少の精査、出血傾向、繰り返す血栓症などで多くの御紹介を頂いております。多血症・骨髄線維症、本態性血小板増加症の診断の鍵となるJAK2変異遺伝子、CALR変異遺伝子、MPL変異遺伝子等の多数の遺伝子検査は院内で実施可能です。
いずれの疾患においても、スタッフが専門的視点から意見を出し合い、最適な治療法を選択し患者さまに提示しております。
防護環境（いわゆる無菌室）
血液内科（けやき棟6階東）病棟全体がクリーンルームとなっております。造血幹細胞移植用の個室（6床、ISO 5準拠）の他、多くの化学療法がクリーンルーム（24床、ISO 7準拠）で行われています。
造血幹細胞移植
血縁者間骨髄移植、血縁者間末梢血幹細胞移植、非血縁者間骨髄移植、臍帯血移植、自己末梢血幹細胞移植のすべてを実施しております。また臨床試験として、移植後シクロフォスファミドを用いたHLA半合致移植（ハプロ移植）、臍帯血移植なども積極的に行っております。
CAR-T
キムリア (一般名：チサゲンレクルユーセル) による治療は、CAR-T療法と呼ばれ、患者さん自身の免疫細胞であるT細胞（Tリンパ球）に遺伝子操作を加えて、白血病細胞への攻撃力を高める治療法で、「がん免疫遺伝子治療」にあたります。筑波大学附属病院は2021年2月にキムリア治療提供可能施設として認定されました。
詳細はこちらへ
詳細はこちらへ
セカンドオピニオン
セカンドオピニオンを目的とした御紹介の場合、予め準備をする為に事前連絡をお願い申し上げます（TEL: 029-853-3560）。
大学院進学を考えているみなさんへ
筑波大学血液内科研究室にようこそ。
医学学系棟研究棟6階に、約300平米の血液内科専有研究スペースがあります。
筑波大学血液内科は若手育成にあたり、伝統的にレジデントによる臨床専門研修と、大学院生による研究とを分離してきました。大学院入学後は研究に専念していただくため、（社会人大学院生以外は）MDであっても患者は受け持ちません。MDの一般大学院生はクリニカル・アシスタント（CA）に就任していただきます（病院からごく僅かですが賃金が支払われます）が、CAとしての任務は月に１～２度の骨髄検査やドナーからの骨髄採取などに限られます。もちろんアルバイトによる収入は保証されています。血液学に興味のあるMD以外のみなさんも、大歓迎です。ぜひ、一緒に研究に取り組みましょう。
[お知らせ] 2021年11月より、トランスボーダー医学研究センター内にも研究室（教室主任 先端血液腫瘍学講座/医学医療系血液内科兼任 坂田麻実子教授）を併設しています。筑波大学血液内科教室とトランスボーダー医学研究センター先端血液腫瘍学講座は、同一のリソースを利用し、連携して運用しています(https://www.md.tsukuba.ac.jp/tmrc/research_lab/advanced_hematooncology/）。
サイエンスとは何か 。サイエンスとは「自分の好きな絵を描く」ような世界です。 私たちの研究室では、血液がん、あるいは造血系の免疫細胞をテーマに、自由にサイエンスの絵を描くことを目指します。具体的には、シングルセル解析やゲノムデータ解析といった「データサイエンス」を得意とし、臨床医学とのパートナーシップを武器に、「ヒトのがん（特に血液がん）」がどのようにして発症するのか「ヒトの血液細胞がどのように発生するのか」、という本質的な課題に迫ります。「ヒトのがん」を対象とするデータサイエンス研究で発見した生物学的事象については、トランスボーダー医学研究センターと連携し、センターが得意とする実験動物学とコラボレーションすることで、ヒトのがんのマウスモデル作製に取り組み、分子病態を本質的に検証することで、将来的には基礎研究の成果を臨床に還元する「Bench to Bed」研究を目指します。
・「ヒトのがん（特に血液がん）」あるいは「血液細胞ができる仕組み」を対象とした最新のデータサイエンス研究を学びたい
・「ヒトのがん（特に血液がん）」あるいは「血液細胞ができる仕組み」を対象とした実験生物学を学びたい 皆さん、ぜひご連絡ください。
大学院博士課程・修士課程・卒業研究生については、
・将来、血液学に関わる医学研究にチャレンジしたい「医学を学んだ、あるいは学んでいる」方
・将来、医学や創薬に関わる研究をしたい「生物学あるいは検査学を学んだ、あるいは学んでいる」方 を広く募集します。
最新データサイエンス研究・実験生物学は、いずれも新たにチャレンジする方にはハードルが高く感じるかもしれませんが、初めてでも大丈夫です。一緒に勉強していきましょう。
連絡先 坂田（柳元）麻実子 SAKATA-YANAGIMOTO Mamiko
sakatama (アットマーク) md.tsukuba.ac.jp
病棟「けやき棟」
2012年末に病棟「けやき棟」が竣工し、血液内科の全ての病床が「けやき棟」に移行しました。「けやき棟」6階東病棟は、病棟全体がクリーンルーム仕様となっています。そのうち6部屋が主に造血幹細胞移植に使用される、高度のクリーンルーム（ISO クラス5）です。
6東病棟の全30床のうち，24床は個室で、入院患者さん方のプライバシーに配慮しています。また患者さんにリラックスして治療を受けて頂けるよう、病棟は木目を基調とした落ち着いた雰囲気で、開放的な造りになっています。また、7東病棟においても専門的な治療（化学療法等）を受けられる環境が整っています。
6東病棟の全30床のうち，24床は個室で、入院患者さん方のプライバシーに配慮しています。また患者さんにリラックスして治療を受けて頂けるよう、病棟は木目を基調とした落ち着いた雰囲気で、開放的な造りになっています。また、7東病棟においても専門的な治療（化学療法等）を受けられる環境が整っています。
けやき棟の全景
けやき棟の正面玄関です。赤いポストがアクセントになっています。
明るく開放的なけやき棟ロビーです。
無菌病棟はけやき棟6階東です。病棟全体がクリーンルーム仕様です。
スタッフステーションも開放的です。
病室（個室）です。
無菌病棟で最も広い病室（個室）です。
筑波山が綺麗に見える病室もあります。
造血幹細胞移植を行う病室です．感染のリスクを下げるため，常に清浄な空気が流れています（ISO クラス5）．この病室では高度で最新の移植医療を行いますが，部屋は木目を基調に広々としていて，リラックスした雰囲気で治療にのぞんで頂けます。
移植病室からの眺め．遠くに H-Ⅱ型ロケットも見えます。
CAR-Tについて
CAR-T細胞療法は、患者さん自身の免疫細胞であるT細胞（Tリンパ球）に遺伝子操作を加えて、白血病細胞への攻撃力を高める治療法で、「がん免疫遺伝子治療」にあたります。CAR-T細胞療法では、まず、患者さんの血液から免疫細胞のひとつであるT細胞を取り出して遺伝子を導入し、CAR（キメラ抗原受容体）と呼ばれる特殊なたんぱく質を細胞の表面にもつT細胞（CAR-T細胞）を作り出します。例えば、B細胞（Bリンパ球）の表面にでている「CD19」と呼ばれる抗原を特異的に認識するCARを有するCAR-T細胞はB細胞に由来する悪性リンパ腫細胞や白血病細胞を特異的に攻撃することができます。このようして製造されたCAR-T細胞を、患者さんの体内に戻すことで治療を行います。
CAR-Tによる治療は、製造管理・品質管理・合併症管理を適正に行うための様々な体制や書類の整備が必要であり、施設認定を受けた施設のみで投与が可能です。
2024年5月現在、筑波大学附属病院ではキムリア (一般名：チサゲンレクルユーセル)とイエスカルタ (一般名：アキシカブタゲンシロルユーセル) という２種類のCAR-Tの治療施設としての施設認定を受けており、上記製品による治療を行うことができます。
キムリアは、再発難治性CD19陽性B細胞性びまん性大細胞型B細胞リンパ腫(DLBCL)・濾胞性リンパ腫(FL)または25歳以下の再発難治性CD19陽性急性リンパ芽球性白血病(B-ALL)に適応、イエスカルタ は縦隔大細胞型B細胞リンパ腫を含む再発難治性大細胞型B細胞リンパ腫に適応となっていますが、 実際に治療が可能かどうかは、専門的な判断が必要となるため、患者さん・ご家族からの直接の問い合わせはお受けしておりません。かかりつけの主治医を介してご相談をお願いします。
＊医療機関の先生方へ
下記の患者紹介用フォームと紹介状を準備していただき地域医療連携室経由でご相談ください。ご不明な点がある場合、お急ぎの場合は当科オンコール医師に直接ご連絡ください。
https://www.kymriah.jp/hcp/treatment/targetpatient.html (キムリア)
https://www.g-station-plus.com/-/media/Files/GStation/forpatient/car-t_support/I-3-file.pdf (イエスカルタ)
(製薬会社提供サイト)
CAR-Tによる治療は、製造管理・品質管理・合併症管理を適正に行うための様々な体制や書類の整備が必要であり、施設認定を受けた施設のみで投与が可能です。
2024年5月現在、筑波大学附属病院ではキムリア (一般名：チサゲンレクルユーセル)とイエスカルタ (一般名：アキシカブタゲンシロルユーセル) という２種類のCAR-Tの治療施設としての施設認定を受けており、上記製品による治療を行うことができます。
キムリアは、再発難治性CD19陽性B細胞性びまん性大細胞型B細胞リンパ腫(DLBCL)・濾胞性リンパ腫(FL)または25歳以下の再発難治性CD19陽性急性リンパ芽球性白血病(B-ALL)に適応、イエスカルタ は縦隔大細胞型B細胞リンパ腫を含む再発難治性大細胞型B細胞リンパ腫に適応となっていますが、 実際に治療が可能かどうかは、専門的な判断が必要となるため、患者さん・ご家族からの直接の問い合わせはお受けしておりません。かかりつけの主治医を介してご相談をお願いします。
＊医療機関の先生方へ
下記の患者紹介用フォームと紹介状を準備していただき地域医療連携室経由でご相談ください。ご不明な点がある場合、お急ぎの場合は当科オンコール医師に直接ご連絡ください。
https://www.kymriah.jp/hcp/treatment/targetpatient.html (キムリア)
https://www.g-station-plus.com/-/media/Files/GStation/forpatient/car-t_support/I-3-file.pdf (イエスカルタ)
(製薬会社提供サイト)
血液内科医を目指している方、筑波大学血液内科に興味のある方へ
筑波大学血液内科にようこそ（2018/4更新）。
これからサブスペシャルティを決めようとしている方へ
あなたは医学部の学生でしょうか。あるいはスーパーローテーション中の研修医でしょうか。血液内科の面白さに目覚めていただけましたか。ローテーションで血液内科を回ったあなたは、血液内科医が非常に内科医らしい実力をもっていることに気づいたことでしょう。すでに経験したように、血液疾患の患者さんは、神経、心血管、肺、肝臓、消化管、腎臓など、身体のあらゆるところに合併症を生じます。血液内科医はこうした全身の合併症に対応する実践的な能力を身につけています。一方、内科的治療で悪性腫瘍の治癒をめざしていることを改めて実感したでしょう。これから研修する研修医のみなさんは、こうした血液内科の姿をよく観察してください。学生のみなさん。血液内科は、基礎医学と臨床医学が患者さんの病歴の中で交差する、大変にダイナミックな専門領域です。一人でも多くの学生のみなさんが血液内科医を目指してくださることを期待しています。
筑波大学附属病院における血液内科の研修は、院内でももっともON/OFFがはっきりしていると言われています。平日夜、週末とも、OFFの場合はリラックスして、趣味なり自分の勉強なり、あるいは研究なりに没頭してください。
筑波大学附属病院における血液内科の研修は、院内でももっともON/OFFがはっきりしていると言われています。平日夜、週末とも、OFFの場合はリラックスして、趣味なり自分の勉強なり、あるいは研究なりに没頭してください。
つくばで血液内科研修を行うことに興味のある方へ
東京の秋葉原駅からつくばエクスプレス快速で終点つくば駅までは45分。駅から筑波大学の広大なキャンパスまでは、散歩するなり、筑波大学循環バスに乗るなりしておいでください。一方、つくば市中心部から成田空港までは車で１時間以内ですので、海外との距離が近いと実感していただけると思います。研究学園都市として都市建設が始まって45年が経過し、研究所と大学だけという当初の環境から、商業施設が適度に混じり合う環境に変貌を遂げました。田園と都市空間が交差し、居住環境も素晴らしくなりました。つくば市は約23万人の人口の10%近い約2万人が研究者（日本人PhDが7000人以上）という、研究学園都市としての特徴が際立ったエリアで、初等中等教育環境にも大変に恵まれています。日本百名山の筑波山を間近に眺め、山麓に広がるフルーツパークも身近な環境で、血液学の研究に没頭してみませんか。
筑波大学は開学時から、「開かれた大学」として発展してきました。筑波大学血液内科は、研修期間、大学以外の研修場所、大学院への進学、あるいは将来設計などについて、各人と相談しながらできるだけ納得のいく選択ができるように支援します。こうした点を含めて、質問がありましたら筑波大学血液内科問い合わせ窓口（sakatama[at]md.tsukuba.ac.jp）までお問い合わせください。
筑波大学は開学時から、「開かれた大学」として発展してきました。筑波大学血液内科は、研修期間、大学以外の研修場所、大学院への進学、あるいは将来設計などについて、各人と相談しながらできるだけ納得のいく選択ができるように支援します。こうした点を含めて、質問がありましたら筑波大学血液内科問い合わせ窓口（sakatama[at]md.tsukuba.ac.jp）までお問い合わせください。
診療内容
外来予定
| 曜日 | 午前（9:00～12:00） | 午後（13:00～17:00） |
|---|---|---|
| 月 | 坂本竜弘, 服部圭一朗，槇島健一 | 坂本竜弘, 服部圭一朗，槇島健一 |
| 火 | 初診外来, 坂田麻実子，加藤貴康 | 坂田麻実子，加藤貴康 |
| 水 | 錦井秀和，栗田尚樹，萩原將太郎(隔週) | 錦井秀和，栗田尚樹 |
| 木 | 初診外来，丸山ゆみ子 | |
| 金 | 小原直，末原泰人，佐々木裕哉 | 小原直，末原泰人，佐々木裕哉， 栗田尚樹(移植後外来) |
受診／紹介方法
- 患者さんが直接予約される場合は、予約センター（029-853-3570）にお電話でご連絡ください。
- 医療機関から直接患者様をご紹介いただく場合は、地域連携室にお電話（029-853-3727）またはFAX（029-853-3712）でご連絡下さい。この場合、担当者が予約に必要な事項をお聞きし、折り返し電話で予約状況をお知らせします（なるべくご希望に添うよう調整いたします）。
- 希望する日時、担当医がございましたらその旨お伝え下さい。
- 紹介状（診療情報提供書）は、予約当日に患者さまがご持参いただいても結構ですし、医療機関から予めFAX（029-853-3712）でお送り頂いても結構です。
- 緊急性が高く、当日診療を要する場合はその旨お伝え下さい。
| 医療機関による予約先：地域連携室 |
TEL: 029-853-3727 |
| FAX: 029-853-3712 | |
| 患者さんによる予約先：予約センター | TEL: 029-853-3570 |
English
- Department of Hematology
- Prof. SAKATA-YANAGIMOTO Mamiko, MD, PhD (linking to Division of Hemato-Oncology, Transborder Medical Research Center)
- Molecular and cellular biology of hematologic malignancies;
Invitation to the fantastic scietific world leaded by SAKATA-YANAGIMOTO Mamiko
https://www.md.tsukuba.ac.jp/tmrc/en/research_lab/advanced_hematooncology/
Contact: sakatama@md.tsukuba.ac.jp
Other Faculty Members
Associate Professor Hidekazu Nishikii: Hematopoietic stem cell biology, Bone marrow stromal cell regulation, Megakaryopoiesis
Assistant Professor Naoki Kurita: Hematopoietic stem cell transplantation, Clinical studies on HSCT & blood diseases
Assistant Professor Takayasu Kato: Molecular mechanisms of acute myeloid leukemia
Assistant Professor Tatushiro Sakamoto: Molecular and cellular research in acute myeloid leukemia
Assistant Professor Keiichiro Hattori: Molecular and cellular research in maligant lymphoma
Assistant Professor Yasuhito Suehara: Molecular and cellular resarch in maligant lymphoma
Assistant Professor Yoshiaki Abe: Molecular and cellular research in malignant lymphoma
Assisant Professor Manabu Fujisawa: Molecular and cellular research in malignant lymphoma
Fellow/Researcher Nguyen Thi Minh Yen
Assistant Professor Naoki Kurita: Hematopoietic stem cell transplantation, Clinical studies on HSCT & blood diseases
Assistant Professor Takayasu Kato: Molecular mechanisms of acute myeloid leukemia
Assistant Professor Tatushiro Sakamoto: Molecular and cellular research in acute myeloid leukemia
Assistant Professor Keiichiro Hattori: Molecular and cellular research in maligant lymphoma
Assistant Professor Yasuhito Suehara: Molecular and cellular resarch in maligant lymphoma
Assistant Professor Yoshiaki Abe: Molecular and cellular research in malignant lymphoma
Assisant Professor Manabu Fujisawa: Molecular and cellular research in malignant lymphoma
Fellow/Researcher Nguyen Thi Minh Yen
Major Clinical Activities
- Diagnosis and Treatment of leukemias, myeloproliferative neoplasms, lymphomas, multiple myelomas, and other hematologic malignancies
- Diagnosis and treatment of bone marrow failure syndromes such as aplastic anemia, myelodysplastic syndrome, and related diseases
- Allogeneic and autologous hematopoietic stem cell transplantation for patients with above diseases; grafts are bone marrow, mobilized peripheral blood, and cord blood cells
- Diagnosis and treatment of hemolytic anemias, immune thrombocytopenic purpura, and other cytopenic diseases
- Diagnosis and treatment of coagulopathies
Major Scientific Interests
- Molecular mechanisms underlying development of hematologic malignancies, particularly myelodysplastic syndrome and malingant lymphomas (using both patient samples and mouse models)
- Stromal cell abnormalities in the bone marrow failure syndromes, including myelosydplastic syndrome (using both patient samples and mouse models)
- Mechanisms of hematopoiesis and ex vivo manipulation of hematopoietic stem/progenitor cells (using human cord blood cells and mouse models)
- Translational research on hematopoietic cell transplantation
Projects for Regular Students in Doctoral or Master’s Programs
- Identification of moleuclar mechanisms how normal hematopoiesis and hematologic malignancies develop: using molecular approach, bioinformatic approach including single cell sequencing and genetic analysis and mouse models
- Identification of stromal cells involved in the bone marrow failure syndromes including myelodyspoastic syndrome
- Identification of megakaryocyte (Mgk) progenitors using a new method and application of Mgk progenitors for ex vivo manipulation
Programs for Short Stay Students (one trimester)
- Learn procedures for sorting progenitor cells from mouse bone marrow and fetal liver using a FACS sorter; bioinformatics using supercomputer to analyze single cell sequencing and genomic sequencing data
- Learn blood cell transplantation in mouse models
Message from foreign students in the lab
Tanzima Nuhat Sharna, PhD student from BangladeshUniversity of Tsukuba, located in southern Ibaraki Prefecture, provides us the opportunity to explore Japanese culture, build our language skill, experience multidisciplinary research environment. Being a part of world-leading innovative university, the department of hematology promotes globalization of researchers by diversified intellectual members. During my work in this laboratory, I came to know about the impressive medical system in Japan. I have received incommensurable support from my supervisor and other lab members to pursue my research. They always encouraged me and motivated to build confidence. Furthermore, I got opportunity to gather high standard theoretical knowledge and practical experience of research in a well-equipped laboratory. We work here with numerous other international students. In addition, we can attend classes and discussions conducted in English which makes an international atmosphere. When I was preparing to apply in the Graduate school of comprehensive human science my supervisor guided me to prepare my applications. Besides, I attended an oral examination for screening process which was conducted in English over the internet. This procedure eliminates my fear of language barrier. Research in Biomedical science is not very developed in Bangladesh. Therefore, when I shall go back to Bangladesh, I would like to introduce my knowledge from Japan for the betterment of my country.
Cao Sy Luan, PhD student from VietnamI am an international student belong the Department of Hematology in University of Tsukuba. First, the reason why I chose this place for studying, because I want to learn about Japanese culture, one of the worthy cultures to learn, study and research about hematological field in professional and modern environment. After more than 3 years studying here, I have been learned a lot of thing, including good characteristics from Japanese, the way of scientific and logical thinking, how to manage experiments and scientific writing skills, the new knowledge not only in hematological but also in clinical, and biomedical filed, and so on. In the Department of Hematology, I have a chance to study and discuss with great and conscientious teachers as well as work together with friendly and kindly lab members. I also got opportunity to attend and represent my study in many conferences in Japan and other countries. I will try to apply as much as possible what I learned from here to contribute to develop my country when I go back. Finally, I greatly appreciate the teaching, helping and encouraging from professor Chiba and all members in the Department of Hematology.
Nguyen Thi Minh Yen, PhD student from VietnamI feel very proud to be a member of the lab. The friendly environment, the enthusiastic help and the devotion of the teachers made me more motivated to continue my research career. In hematology lab, I have learned a lot of new techniques, new knowledge in biomedical field, pathology, especially the way of thinking scientifically to solve research problems. Along with a great deal of hematological pathology, I believe this is a fascinating field to explore new biological mechanisms and, from that point of view, solves the problem of unique therapeutic drugs for treatment cancer diseases, particularly hematological neoplasm.
Actually, the number of hematologic cancer patients are rising in anxiety in our country. As a student from Vietnam, I think here is a worthy place to contribute and learn to hope that new opportunities for hematologic cancer patients will come true.
Raksha Shrestha, PhD student from NepalEnrolling in the Doctoral program in Clinical Hematology at University of Tsukuba was one of the best decisions I have made in my life. Being one of the most highly research-intensive and respected universities in Japan, University of Tsukuba upholds its reputation for excellence with outstanding graduate programs like ours, in the department of hematology. Creative thinking, active discussions and strong mentor-student relationships are some among many positive attributes of the program. I have thoroughly enjoyed learning new techniques in the lab, reading broadly around my areas of interest and hearing about current research from local and visiting academics. A unique blend of interpersonal dynamics, strong work ethic and great camaraderie among the team creates a supportive and an amicable atmosphere in the lab. I believe that the knowledge and experience I acquire here will help me become an independent and competent clinician scientist in future. I feel immensely proud and equally grateful to be a part of this wonderful team at University of Tsukuba. Thank you for making it ‘my home away from home’.
Recent activities
In front of a Soba restaurant (lab members with Prof P. Gaulard.)
Recent Publications
・Abe Y, Sakata-Yanagimoto M, Fujisawa M, Miyoshi H, Suehara Y, Hattori K, Kusakabe M, Sakamoto T, Nishikii H, Nguyen TB, Owada Y, Enomoto T, Sawa A, Bando H, Yoshida C, Tabata R, Terao T, Nakayama M, Ohshima K, Usuki K, Oda T, Matsue K, Chiba S. A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling. Nat Cell Biol (doi: 10.1038/s41556-022-00866-3.) Online ahead of print Mar 24, 2022
・Ikezoe T, Noji H, Ueda Y, Kanda Y, Okamoto S, Usuki K, Matsuda T, Akiyama H, Shimono A, Yonemura Y, Kawaguchi T, Chiba S, Kanakura Y, Nishimura JI, Ninomiya H, Obara N. Long-term follow-up of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: post-marketing surveillance in Japan. Int J Hematol 115(4):470-480, Apr, 2022 (doi: 10.1007/s12185-022-03287-y.) Epub Feb 11, 2022
・Perl AE, Larson RA, Podoltsev NA, Strickland SA, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Récher C, Yoon SS, Hosono N, Onozawa M, Chiba S, Kim HJ, Hasabou N, Lu Q, Tiu R, Levis MJ. Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial. Blood (doi: 10.1182/blood.2021011583.) Online ahead of print Jan 26, 2022
・Matsuoka R, Sakamoto N, Kato T, Chiba S, Noguchi M. A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains. Eur J Med Res 26(1):148, Dec 20, 2021 (doi: 10.1186/s40001-021-00621-8.)
・Suma S, Yokoyama Y, Momose H, Makishima K, Kiyoki Y, Sakamoto T, Kusakabe M, Kato T, Kurita N, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure. Intern Med (doi: 10.2169/internalmedicine.7836-21.) Online ahead of print Nov 20, 2021
・Makishima K, Suehara Y, Abe Y, Hattori K, Kusakabe M, Matsuoka R, Chiba S, Sakata-Yanagimoto M. Intratumor heterogeneity of lymphoma identified by multiregion sequencing of autopsy samples. Cancer Sci 113(1):362-364, Jan, 2022 (doi: 10.1111/cas.15178. ) Epub Nov 21, 2021
・Nguyen YTM, Fujisawa M, Nguyen TB, Suehara Y, Tatsuhiro S, Matsuoka R, Abe Y, Fukumoto K, Hattori K, Noguchi M, Matsubara D, Chiba S, Sakata-Yanagimoto M. Tet2-deficency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model. Cancer Sci 112(12):4931-4943, Dec, 2021 (doi: 10.1111/cas.15165.) Epub Oct 17, 2021
・Kaji D, Kusakabe M, Sakata-Yanagimoto M, Makishima K, Suehara Y, Hattori K, Ota Y, Mitsuki T, Yuasa M, Kageyama K, Taya Y, Nishida A, Ishiwata K, Takagi S, Yamamoto H, Asano-Mori Y, Ubara Y, Izutsu K, Uchida N, Wake A, Taniguchi S, Yamamoto G, Chiba S. Retrospective analyses of other iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with rheumatic diseases. Br J Haematol 195(4):585-594, Nov, 2021 (doi: 10.1111/bjh.17824.) Epub Sep 23, 2021
・Hosono N, Yokoyama H, Aotsuka N, Ando K, Iida H, Ishikawa T, Usuki K, Onozawa M, Kizaki M, Kubo K, Kuroda J, Kobayashi Y, Shimizu T, Chiba S, Nara M, Hata T, Hidaka M, Fujiwara SI, Maeda Y, Morita Y, Kusano M, Lu Q, Miyawaki S, Berrak E, Hasabou N, Naoe T. Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia. Int J Clin Oncol 26(11):2131-2141 Nov, 2021 (doi: 10.1007/s10147-021-02006-7.) Epub Aug 7, 2021
・Niemi MEK, et al., Chiba S, et al. (1224人中1093番目) Mapping the human genetic architecture of COVID-19. Nature 600(7889):472-477, Dec, 2021(doi.org/10.1038/s41586-021-03767-x) Epub Jul 8, 2021
・Hibino S, Kawazoe T, Kasahara H, Itoh S, Ishimoto T, Sakata-Yanagimoto M, Taniguchi K. Inflammation-Induced Tumorigenesis and Metastasis. Int J Mol Sci 22(11):5421, May 21, 2021 (doi: 10.3390/ijms22115421.)
・Kurosawa S, Kaito S, Uchida N, Fukuda T, Doki N, Mori T, Hasegawa Y, Takada S, Sakaida E, Tanaka M, Ikegame K, Kanda J, Atsuta Y, Kako S. Allogeneic hematopoietic stem cell transplantation for adult patients with B-cell acute lymphoblastic leukemia with high hyperdiploidy: a retrospective nationwide study. Leuk Lymphoma 62(10):2514-2520, Oct, 2021 (doi: 10.1080/10428194.2021.1924374.) Epub May 12, 2021
・Nangaku M, Kadowaki T, Yotsuyanagi H, Ohmagari N, Egi M, Sasaki J, Sakamoto T, Hasegawa Y, Ogura T, Chiba S, Node K, Suzuki R, Yamaguchi Y, Murashima A, Ikeda N, Morishita E, Yuzawa K, Moriuchi H, Hayakawa S, Nishi D, Irisawa A, Miyamoto T, Suzuki H, Sone H, Fujino Y. The Japanese Medical Science Federation COVID-19 Expert Opinion English Version. JMA J 4(2):148-162, Apr 15, 2021 (doi: 10.31662/jmaj.2021-0002.) Epub Apr 8, 2021
・Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Elias HK, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Nat Med 27(5):927, May, 2021 (doi: 10.1038/s41591-021-01367-w.) Epub May 4, 2021
・Inoue K, Iida N, Tajiri K, Bando H, Chiba S, Tasaka N, Nagashio K, Sasamura R, Naito H, Murata M, Li S, Ishizu T, Nakazawa Y, Sekine I, Ieda M. Rationale, Design, and Feasibility of a Prospective Multicenter Registry Study of Anthracycline-Induced Cardiotoxicity (AIC Registry) J Clin Med 10(7):1370, Mar 27, 2021 (doi: 10.3390/jcm10071370.)
・Kawai H, Ando K, Maruyama D, Yamamoto K, Kiyohara E, Terui Y, Fukuhara N, Miyagaki T, Tokura Y, Sakata-Yanagimoto M, Igarashi T, Kuroda J, Fujita J, Uchida T, Ishikawa T, Yonekura K, Kato K, Nakanishi T, Nakai K, Matsunaga R, Tobinai K. Phase 2 study of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma. Cancer Sci 112(6):2426-2435, Jun, 2021 (doi: 10.1111/cas.14906.) Epub Mar 31, 2021
・Sakakibara A, Suzuki Y, Kato H, Yamamoto K, Sakata-Yanagimoto M, Ishikawa Y, Furukawa K, Shimada K, Kohno K, Nakamura S, Satou A, Kato S. Follicular T-cell lymphoma mimicking lymphocyte-rich classic Hodgkin lymphoma: a case report of a diagnostic pitfall. J Clin Exp Hematop 61(2):97-101, Jun 5, 2021 (doi: 10.3960/jslrt.20052.) Epub Mar 15, 2021
・Sakata-Yanagimoto M, Fukumoto K, Karube K, Chiba S. Molecular understanding of peripheral T-cell lymphomas, not otherwise specified (PTCL, NOS): A complex disease category. J Clin Exp Hematop 61(2):61-70, Jun 5, 2021(doi: 10.3960/jslrt.20059.) Epub Mar 15, 2021
・Kurita N, Sakamoto T, Kato T, Kusakabe M, Yokoyama Y, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. Early administration of cyclosporine may reduce the incidence of cytokine release syndrome after HLA-haploidentical hematopoietic stem-cell transplantation with post-transplant cyclophosphamide. Ann Hematol 100(5):1295-1301, May, 2021 (doi: 10.1007/s00277-021-04439-6.) Epub Feb 12, 2021
・Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med 27(3):562, Mar, 2021(doi: 10.1038/s41591-021-01253-5.) Epub Feb 9, 2021
・Tanaka A, Yokohama A, Fujiwara SI, Fujii Y, Kaneko M, Ueda Y, Abe T, Kato Y, Hasegawa Y, Ikeda K, Fujino K, Matsumoto M, Makino S, Kino S, Takeshita A, Muroi K. Transfusion-associated circulatory overload and high blood pressure: A multicentre retrospective study in Japan. Vox Sang 116(7):785-792, Aug, 2021 (doi: 10.1111/vox.13063.) Epub Feb 2, 2021
・Narita K, Kobayashi H, Suzuki T, Ichikawa D, Yamazaki K, Terawaki H, Suehara Y, Miura D, Takeuchi M, Matsue K. Light Chain Deposition Disease in a Patient With MYD88 L265P Mutation-positive Low-grade B-cell Lymphoma and Monoclonal Immunoglobulin G κ. Clin Lymphoma Myeloma Leuk 20(11):e805-e808, Nov, 2020 (doi: 10.1016/j.clml.2020.06.006.) Epub 2020 Jun 13.
・Yanagimachi N, Obara N, Sakata-Yanagimoto M, Chiba S, Doki K, Homma M. A simple high-performance liquid chromatography assay for determining eltrombopag concentration in human serum. Biomed Chromatogr e5049, Dec 11, 2020 (doi: 10.1002/bmc.5049.) Online ahead of print.
・Shikata H, Kihara H, Kaneko M, Matsukage S, Hattori K. Monitoring of MYD88 L265P mutation by droplet digital polymerase chain reaction for prediction of early relapse in a patient with Bing-Neel syndrome. Int J Hematol Nov 22, 2020 (doi: 10.1007/s12185-020-03038-x.) Online ahead of print.
・Imada K, Obara N, Iida H, Imajo K, Maeda T, Usuki K, Fanghong Z, Hombo Y, Tajima T, Kumagai A, Matsuda A, Nakao S. Eltrombopag in Combination with Rabbit Anti-thymocyte Globulin/Cyclosporine A in Immunosuppressive Therapy-naïve Patients with Aplastic Anemia in Japan. Intern Med 2020 Nov 23. (doi: 10.2169/internalmedicine.6063-20.) Online ahead of print.
・Hosokawa K, Ishiyama K, Ikemoto T, Sugimori C, Noji H, Shichishima T, Obara N, Chiba S, Ninomiya H, Nguyen MAT, Shirasugi Y, Nakamura Y, Ando K, Ueda Y, Yonemura Y, Kawaguchi T, Nishimura JI, Kanakura Y, Nakao S. The clinical significance of PNH-phenotype cells accounting for < 0.01% of total granulocytes detected by the Clinical and Laboratory Standards Institute methods in patients with bone marrow failure. Ann Hematol Oct 23, 2020 (doi: 10.1007/s00277-020-04314-w.) Online ahead of print.
・Matsuoka R, Sakamoto N, Sakata-Yanagimoto M, Chiba S, Noguchi M, Nakamura N. An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma. J Clin Exp Hematop 60(4):169-173, Dec 15, 2020 (doi: 10.3960/jslrt.20022. ) Epub Oct 8, 2020
・Fukumoto K, Sakata-Yanagimoto M, Fujisawa M, Sakamoto T, Miyoshi H, Suehara Y, Nguyen TB, Suma S, Yanagimoto S, Shiraishi Y, Chiba K, Bouska A, Kataoka K, Ogawa S, Iqbal J, Ohshima K, Chiba S. VAV1 mutations contribute to development of T-cell neoplasms in mice. Blood Sep 29, 2020 (doi: 10.1182/blood.2020006513.) Online ahead of print.
・Kaji D, Ota Y, Sato Y, Nagafuji K, Ueda Y, Okamoto M, Terasaki Y, Tsuyama N, Matsue K, Kinoshita T, Yamamoto G, Taniguchi S, Chiba S, Ohshima K, Izutsu K. Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis. Blood Adv 4(18):4442-4450, Sep 22, 2020 (doi: 10.1182/bloodadvances.2020002293.)
・Kiyoki Y, Matsuoka R, Kaneta T, Nishikii H. 18FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia. Int J Hematol 112(4):433-434, Oct, 2020 (doi: 10.1007/s12185-020-02976-w.) Epub Aug 31, 2020
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・Konishi R, Ishitsuka Y, Inoue S, Saito A, Nakamura Y, Watanabe R, Okiyama N, Chiba S, Nishikii H, Fujimoto M, Fujisawa Y. Aggressive conjunctival carcinoma arising on poorly controlled sun-damaged graft-versus-host disease. Eur J Dermatol 30(3):313-314, Jun 1, 2020 (doi: 10.1684/ejd.2020.3779.)
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・Yokoyama Y, Maie K, Fukuda T, Uchida N, Mukae J, Sawa M, Kubo K, Kurokawa M, Nakamae H, Ichinohe T, Atsuta Y, Chiba S. A High CD34 + Cell Dose Is Associated With Better Disease-Free Survival in Patients With Low-Risk Diseases Undergoing Peripheral Blood Stem Cell Transplantation From HLA-matched Related Donors. Bone Marrow Transplant 55(9):1726-1735, Sep, 2020 (doi: 10.1038/s41409-020-0817-5) Epub Feb 10, 2020
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・Miki K, Obara N, Makishima K, Sakamoto T, Kusakabe M, Kato T, Kurita N, Nishikii H, Yokoyama Y, Sakata-Yanagimoto M, Hasegawa Y, Chiba S. An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature. Case Rep Hematol 2018:7863943, Oct 10, 2018 (doi: 10.1155/2018/7863943.) eCollection 2018.
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・Nishikii H, Kanazawa Y, Umemoto T, Goltsev Y, Matsuzaki Y, Matsushita K, Yamato M, Nolan GP, Negrin R, Chiba S. Unipotent megakaryopoietic pathway bridging hematopoietic stem cells and mature megakaryocytes. Stem Cells. 33(7):2196-207, 2015
・Kasenda B, Ferreri AJ, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay JY, Hoang-Xuan K, Pulczynski EJ, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill BP, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor TT, Illerhaus G, Briel M. First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) - A Systematic Review and Individual Patient Data Meta-Analysis. Ann Oncol. 26(7):1305-13, 2015
・Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia. 29(3):576-85, 2015
・Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchiba K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S. Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice. Blood Cancer J. 4:e264, 2014
・Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 46(2):171-5, 2014
・Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 478(7367):64-9, 2011
・Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood. 117(1):128-34, 2011
・Ikezoe T, Noji H, Ueda Y, Kanda Y, Okamoto S, Usuki K, Matsuda T, Akiyama H, Shimono A, Yonemura Y, Kawaguchi T, Chiba S, Kanakura Y, Nishimura JI, Ninomiya H, Obara N. Long-term follow-up of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: post-marketing surveillance in Japan. Int J Hematol 115(4):470-480, Apr, 2022 (doi: 10.1007/s12185-022-03287-y.) Epub Feb 11, 2022
・Perl AE, Larson RA, Podoltsev NA, Strickland SA, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Récher C, Yoon SS, Hosono N, Onozawa M, Chiba S, Kim HJ, Hasabou N, Lu Q, Tiu R, Levis MJ. Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial. Blood (doi: 10.1182/blood.2021011583.) Online ahead of print Jan 26, 2022
・Matsuoka R, Sakamoto N, Kato T, Chiba S, Noguchi M. A case of solitary plasmacytoma of bone showing co-expression of both immunoglobulin light chains. Eur J Med Res 26(1):148, Dec 20, 2021 (doi: 10.1186/s40001-021-00621-8.)
・Suma S, Yokoyama Y, Momose H, Makishima K, Kiyoki Y, Sakamoto T, Kusakabe M, Kato T, Kurita N, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure. Intern Med (doi: 10.2169/internalmedicine.7836-21.) Online ahead of print Nov 20, 2021
・Makishima K, Suehara Y, Abe Y, Hattori K, Kusakabe M, Matsuoka R, Chiba S, Sakata-Yanagimoto M. Intratumor heterogeneity of lymphoma identified by multiregion sequencing of autopsy samples. Cancer Sci 113(1):362-364, Jan, 2022 (doi: 10.1111/cas.15178. ) Epub Nov 21, 2021
・Nguyen YTM, Fujisawa M, Nguyen TB, Suehara Y, Tatsuhiro S, Matsuoka R, Abe Y, Fukumoto K, Hattori K, Noguchi M, Matsubara D, Chiba S, Sakata-Yanagimoto M. Tet2-deficency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model. Cancer Sci 112(12):4931-4943, Dec, 2021 (doi: 10.1111/cas.15165.) Epub Oct 17, 2021
・Kaji D, Kusakabe M, Sakata-Yanagimoto M, Makishima K, Suehara Y, Hattori K, Ota Y, Mitsuki T, Yuasa M, Kageyama K, Taya Y, Nishida A, Ishiwata K, Takagi S, Yamamoto H, Asano-Mori Y, Ubara Y, Izutsu K, Uchida N, Wake A, Taniguchi S, Yamamoto G, Chiba S. Retrospective analyses of other iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with rheumatic diseases. Br J Haematol 195(4):585-594, Nov, 2021 (doi: 10.1111/bjh.17824.) Epub Sep 23, 2021
・Hosono N, Yokoyama H, Aotsuka N, Ando K, Iida H, Ishikawa T, Usuki K, Onozawa M, Kizaki M, Kubo K, Kuroda J, Kobayashi Y, Shimizu T, Chiba S, Nara M, Hata T, Hidaka M, Fujiwara SI, Maeda Y, Morita Y, Kusano M, Lu Q, Miyawaki S, Berrak E, Hasabou N, Naoe T. Gilteritinib versus chemotherapy in Japanese patients with FLT3-mutated relapsed/refractory acute myeloid leukemia. Int J Clin Oncol 26(11):2131-2141 Nov, 2021 (doi: 10.1007/s10147-021-02006-7.) Epub Aug 7, 2021
・Niemi MEK, et al., Chiba S, et al. (1224人中1093番目) Mapping the human genetic architecture of COVID-19. Nature 600(7889):472-477, Dec, 2021(doi.org/10.1038/s41586-021-03767-x) Epub Jul 8, 2021
・Hibino S, Kawazoe T, Kasahara H, Itoh S, Ishimoto T, Sakata-Yanagimoto M, Taniguchi K. Inflammation-Induced Tumorigenesis and Metastasis. Int J Mol Sci 22(11):5421, May 21, 2021 (doi: 10.3390/ijms22115421.)
・Kurosawa S, Kaito S, Uchida N, Fukuda T, Doki N, Mori T, Hasegawa Y, Takada S, Sakaida E, Tanaka M, Ikegame K, Kanda J, Atsuta Y, Kako S. Allogeneic hematopoietic stem cell transplantation for adult patients with B-cell acute lymphoblastic leukemia with high hyperdiploidy: a retrospective nationwide study. Leuk Lymphoma 62(10):2514-2520, Oct, 2021 (doi: 10.1080/10428194.2021.1924374.) Epub May 12, 2021
・Nangaku M, Kadowaki T, Yotsuyanagi H, Ohmagari N, Egi M, Sasaki J, Sakamoto T, Hasegawa Y, Ogura T, Chiba S, Node K, Suzuki R, Yamaguchi Y, Murashima A, Ikeda N, Morishita E, Yuzawa K, Moriuchi H, Hayakawa S, Nishi D, Irisawa A, Miyamoto T, Suzuki H, Sone H, Fujino Y. The Japanese Medical Science Federation COVID-19 Expert Opinion English Version. JMA J 4(2):148-162, Apr 15, 2021 (doi: 10.31662/jmaj.2021-0002.) Epub Apr 8, 2021
・Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Elias HK, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Nat Med 27(5):927, May, 2021 (doi: 10.1038/s41591-021-01367-w.) Epub May 4, 2021
・Inoue K, Iida N, Tajiri K, Bando H, Chiba S, Tasaka N, Nagashio K, Sasamura R, Naito H, Murata M, Li S, Ishizu T, Nakazawa Y, Sekine I, Ieda M. Rationale, Design, and Feasibility of a Prospective Multicenter Registry Study of Anthracycline-Induced Cardiotoxicity (AIC Registry) J Clin Med 10(7):1370, Mar 27, 2021 (doi: 10.3390/jcm10071370.)
・Kawai H, Ando K, Maruyama D, Yamamoto K, Kiyohara E, Terui Y, Fukuhara N, Miyagaki T, Tokura Y, Sakata-Yanagimoto M, Igarashi T, Kuroda J, Fujita J, Uchida T, Ishikawa T, Yonekura K, Kato K, Nakanishi T, Nakai K, Matsunaga R, Tobinai K. Phase 2 study of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma. Cancer Sci 112(6):2426-2435, Jun, 2021 (doi: 10.1111/cas.14906.) Epub Mar 31, 2021
・Sakakibara A, Suzuki Y, Kato H, Yamamoto K, Sakata-Yanagimoto M, Ishikawa Y, Furukawa K, Shimada K, Kohno K, Nakamura S, Satou A, Kato S. Follicular T-cell lymphoma mimicking lymphocyte-rich classic Hodgkin lymphoma: a case report of a diagnostic pitfall. J Clin Exp Hematop 61(2):97-101, Jun 5, 2021 (doi: 10.3960/jslrt.20052.) Epub Mar 15, 2021
・Sakata-Yanagimoto M, Fukumoto K, Karube K, Chiba S. Molecular understanding of peripheral T-cell lymphomas, not otherwise specified (PTCL, NOS): A complex disease category. J Clin Exp Hematop 61(2):61-70, Jun 5, 2021(doi: 10.3960/jslrt.20059.) Epub Mar 15, 2021
・Kurita N, Sakamoto T, Kato T, Kusakabe M, Yokoyama Y, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. Early administration of cyclosporine may reduce the incidence of cytokine release syndrome after HLA-haploidentical hematopoietic stem-cell transplantation with post-transplant cyclophosphamide. Ann Hematol 100(5):1295-1301, May, 2021 (doi: 10.1007/s00277-021-04439-6.) Epub Feb 12, 2021
・Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med 27(3):562, Mar, 2021(doi: 10.1038/s41591-021-01253-5.) Epub Feb 9, 2021
・Tanaka A, Yokohama A, Fujiwara SI, Fujii Y, Kaneko M, Ueda Y, Abe T, Kato Y, Hasegawa Y, Ikeda K, Fujino K, Matsumoto M, Makino S, Kino S, Takeshita A, Muroi K. Transfusion-associated circulatory overload and high blood pressure: A multicentre retrospective study in Japan. Vox Sang 116(7):785-792, Aug, 2021 (doi: 10.1111/vox.13063.) Epub Feb 2, 2021
・Narita K, Kobayashi H, Suzuki T, Ichikawa D, Yamazaki K, Terawaki H, Suehara Y, Miura D, Takeuchi M, Matsue K. Light Chain Deposition Disease in a Patient With MYD88 L265P Mutation-positive Low-grade B-cell Lymphoma and Monoclonal Immunoglobulin G κ. Clin Lymphoma Myeloma Leuk 20(11):e805-e808, Nov, 2020 (doi: 10.1016/j.clml.2020.06.006.) Epub 2020 Jun 13.
・Yanagimachi N, Obara N, Sakata-Yanagimoto M, Chiba S, Doki K, Homma M. A simple high-performance liquid chromatography assay for determining eltrombopag concentration in human serum. Biomed Chromatogr e5049, Dec 11, 2020 (doi: 10.1002/bmc.5049.) Online ahead of print.
・Shikata H, Kihara H, Kaneko M, Matsukage S, Hattori K. Monitoring of MYD88 L265P mutation by droplet digital polymerase chain reaction for prediction of early relapse in a patient with Bing-Neel syndrome. Int J Hematol Nov 22, 2020 (doi: 10.1007/s12185-020-03038-x.) Online ahead of print.
・Imada K, Obara N, Iida H, Imajo K, Maeda T, Usuki K, Fanghong Z, Hombo Y, Tajima T, Kumagai A, Matsuda A, Nakao S. Eltrombopag in Combination with Rabbit Anti-thymocyte Globulin/Cyclosporine A in Immunosuppressive Therapy-naïve Patients with Aplastic Anemia in Japan. Intern Med 2020 Nov 23. (doi: 10.2169/internalmedicine.6063-20.) Online ahead of print.
・Hosokawa K, Ishiyama K, Ikemoto T, Sugimori C, Noji H, Shichishima T, Obara N, Chiba S, Ninomiya H, Nguyen MAT, Shirasugi Y, Nakamura Y, Ando K, Ueda Y, Yonemura Y, Kawaguchi T, Nishimura JI, Kanakura Y, Nakao S. The clinical significance of PNH-phenotype cells accounting for < 0.01% of total granulocytes detected by the Clinical and Laboratory Standards Institute methods in patients with bone marrow failure. Ann Hematol Oct 23, 2020 (doi: 10.1007/s00277-020-04314-w.) Online ahead of print.
・Matsuoka R, Sakamoto N, Sakata-Yanagimoto M, Chiba S, Noguchi M, Nakamura N. An overlapping case of in situ mantle cell neoplasia and leukemic non-nodal mantle cell lymphoma. J Clin Exp Hematop 60(4):169-173, Dec 15, 2020 (doi: 10.3960/jslrt.20022. ) Epub Oct 8, 2020
・Fukumoto K, Sakata-Yanagimoto M, Fujisawa M, Sakamoto T, Miyoshi H, Suehara Y, Nguyen TB, Suma S, Yanagimoto S, Shiraishi Y, Chiba K, Bouska A, Kataoka K, Ogawa S, Iqbal J, Ohshima K, Chiba S. VAV1 mutations contribute to development of T-cell neoplasms in mice. Blood Sep 29, 2020 (doi: 10.1182/blood.2020006513.) Online ahead of print.
・Kaji D, Ota Y, Sato Y, Nagafuji K, Ueda Y, Okamoto M, Terasaki Y, Tsuyama N, Matsue K, Kinoshita T, Yamamoto G, Taniguchi S, Chiba S, Ohshima K, Izutsu K. Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis. Blood Adv 4(18):4442-4450, Sep 22, 2020 (doi: 10.1182/bloodadvances.2020002293.)
・Kiyoki Y, Matsuoka R, Kaneta T, Nishikii H. 18FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia. Int J Hematol 112(4):433-434, Oct, 2020 (doi: 10.1007/s12185-020-02976-w.) Epub Aug 31, 2020
・Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med 26(10):1549-1556, Oct, 2020 (doi: 10.1038/s41591-020-1008-z.) Epub Aug 3, 2020
・Yokohama A, Okuyama Y, Ueda Y, Itoh M, Fujiwara SI, Hasegawa Y, Nagai K, Arakawa K, Miyazaki K, Makita M, Watanabe M, Ikeda K, Tanaka A, Fujino K, Matsumoto M, Makino S, Kino S, Takeshita A, Muroi K. Differences among hemoglobin thresholds for red blood cell transfusions in patients with hematological diseases in teaching hospitals: a real world data in Japan. Int J Hematol 112(4):535-543, Oct, 2020 (doi: 10.1007/s12185-020-02937-3.) Epub Jul 18, 2020
・Chiba S, Sakata-Yanagimoto M. Advances in understanding of angioimmunoblastic T-cell lymphoma. Leukemia 34(10):2592-2606, Oct, 2020 (doi: 10.1038/s41375-020-0990-y.) Epub Jul 23, 2020 Review.
・Konishi R, Ishitsuka Y, Inoue S, Saito A, Nakamura Y, Watanabe R, Okiyama N, Chiba S, Nishikii H, Fujimoto M, Fujisawa Y. Aggressive conjunctival carcinoma arising on poorly controlled sun-damaged graft-versus-host disease. Eur J Dermatol 30(3):313-314, Jun 1, 2020 (doi: 10.1684/ejd.2020.3779.)
・Miyoshi H, Sakata-Yanagimoto M, Shimono J, Yoshida N, Hattori K, Arakawa F, Yanagida E, Takeuchi M, Yamada K, Suzuki T, Moritsubo M, Furuta T, Chiba S, Ohshima K. RHOA mutation in follicular T-cell lymphoma: Clinicopathological analysis of 16 cases. Pathol Int 70(9):653-660, Sep, 2020 ( doi: 10.1111/pin.12981.) Epub Jul 9, 2020
・Kurosawa S, Yamaguchi H, Yamaguchi T, Fukunaga K, Yui S, Kanamori H, Usuki K, Uoshima N, Yanada M, Takeuchi J, Mizuno I, Kanda J, Okamura H, Yano S, Tashiro H, Shindo T, Chiba S, Tomiyama J, Inokuchi K, Fukuda T. The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse. Int J Hematol 112(2):200-209, Aug, 2020 (doi: 10.1007/s12185-020-02894-x.) Epub Jun 3, 2020
・Fujita H, Ishikawa Y, Yokoyama Y. JSH practical guidelines for hematological malignancies, 2018: I. Leukemia-2. Acute promyelocytic leukemia (APL). Int J Hematol 111(6):747-760, Jun, 2020 (doi: 10.1007/s12185-020-02884-z.) Epub Apr 28, 2020
・Fujiwara SI, Ikeda K, Kino S, Tanaka A, Hasegawa Y, Fujino K, Makino S, Matsumoto M, Yokohama A, Takeshita A, Muroi K. Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors. Int J Hematol 111(6):833-839, Jun, 2020 (doi: 10.1007/s12185-020-02851-8.) Epub Mar 14, 2020
・Shrestha R, Sakata-Yanagimoto M, Maie K, Oshima M, Ishihara M, Suehara Y, Fukumoto K, Nakajima-Takagi Y, Matsui H, Kato T, Muto H, Sakamoto T, Kusakabe M, Nannya Y, Makishima H, Ueno H, Saiki R, Ogawa S, Chiba K, Shiraishi Y, Miyano S, Enguerran Mouly, Bernard OA, Inaba T, Koseki H , Iwama A, Chiba S. Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status. Blood Adv 4(5):845-854, Mar 10, 2020 (doi: 10.1182/bloodadvances.2019001324)
・Yamada C, Takeshita A, Ohto H, Ishimaru K, Kawabata K, Nomaguchi Y, Haraguchi Y, Abe M, Sobue K, Takenouchi H, Takadate J, Kamimura M, Katai A, Kasai D, Minami Y, Sugimoto T, Michino J, Nagai K, Kumagai M, Hasegawa Y, Ishizuka K, Ohtomo N, Yamada N, Muroi K, Matsushita T, Takahashi K. A Japanese Multi-Institutional Collaborative Study of Antigen-Positive Red Blood Cell (RBC) Transfusions in Patients With Corresponding RBC Antibodies. Vox Sang 115(5):456-465, Jul, 2020 (doi: 10.1111/vox.12906) Epub Mar 2, 2020
・Nguyen TB, Sakata-Yanagimoto M, Fujisawa M, Tanzima Nuhat S, Miyoshi H, Nannya Y, Hashimoto K, Fukumoto K, Bernard Olivier A, Kiyoki Y, Ishitsuka K, Momose H, Sukegawa S, Shinagawa A, Suyama T, SatoY, Nishikii H, Obara N, Kusakabe M, Yanagimoto S, Ogawa S, Ohshima K, Chiba S. Dasatinib Is an Effective Treatment for Angioimmunoblastic T-cell Lymphoma. Cancer Res 80(9):1875-1884, May 1, 2020 (doi: 10.1158/008-5472.CAN-19-2787) Epub Feb 27, 2020
・Yokoyama Y, Maie K, Fukuda T, Uchida N, Mukae J, Sawa M, Kubo K, Kurokawa M, Nakamae H, Ichinohe T, Atsuta Y, Chiba S. A High CD34 + Cell Dose Is Associated With Better Disease-Free Survival in Patients With Low-Risk Diseases Undergoing Peripheral Blood Stem Cell Transplantation From HLA-matched Related Donors. Bone Marrow Transplant 55(9):1726-1735, Sep, 2020 (doi: 10.1038/s41409-020-0817-5) Epub Feb 10, 2020
・Ishikawa Y, Kawashima N, Atsuta Y, Sugiura I, Sawa M, Dobashi N, Yokoyama H, Doki N, Tomita A, Kiguchi T, Koh S, Kanamori H, Iriyama N, Kohno A, Moriuchi Y, Asada N, Hirano D, Togitani K, Sakura T, Hagihara M, Tomikawa T, Yokoyama Y, Asou N, Ohtake S, Matsumura I, Miyazaki Y, Naoe T, Kiyoi H. Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11. Blood Adv 4(1):66-75, Jan 14, 2020 (doi: 10.1182/bloodadvances.2019000709.)
・Suma-Sugimoto S, Yokoyama Y, Yoshida C, Ishitsuka K, Makishima K, Kiyoki Y, Sakamoto T, Kusakabe M, Kato T, Kurita N, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. Salvage Cord Blood Transplantation Using a Short-Term Reduced-Intensity Preparative Regimen for Graft Failure. Clin Lymphoma Myeloma Leuk 19(1):S261–S262, Sep, 2019 (doi: 10.1016/j.clml.2019.07.179)
・Eladl AE, Shimada K, Suzuki Y, Takahara T, Kato S, Kohno K, Elsayed AA, Wu CC, Tokunaga T, Kinoshita T, Sakata-Yanagimoto M, Nakamura S, Satou A. EBV status has prognostic implication among young patients with angioimmunoblastic T-cell lymphoma. Cancer Med 9(2):678-688, Jan, 2020 (doi: 10.1002/cam4.2742.) Epub Dec 2, 2019
・Kumar P, Lele SS, Ragothaman VK, Raghunathan D, Epstein AL, Chiba S, Prabhakar BS. OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling. J Immunol 203(12):3225-3236, Dec 15, 2019 (doi: 10.4049/jimmunol.1900530.) Epub Nov 8, 2019
・Suehara Y, Sakata-Yanagimoto M, Hattori K, Kusakabe M, Nanmoku T, Sato T, Noguchi M, Chiba S. Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis. Cancer Sci 110(10):3375-3381, Oct, 2019 (doi: 10.1111/cas.14176.) Epub Sep 12, 2019
・Kawabata H, Usuki K, Shindo-Ueda M, Kanda J, Tohyama K, Matsuda A, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Miyazaki Y, Kurokawa M, Arai S, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes. Serum ferritin levels at diagnosis predict prognosis in patients with low blast count myelodysplastic syndromes. Int J Hematol 110(5):533-542, Nov, 2019 (doi: 10.1007/s12185-019-02710-1. ) Epub Jul 29, 2019
・Yoshida I, Tamura K, Miyamoto T, Shimokawa M, Takamatsu Y, Nanya Y, Matsumura I, Gotoh M, Igarashi T, Takahashi T, Aiba K, Kumagai K, Ishizawa K, Kurita N, Usui N, Hatake K. Prophylactic Antiemetics for Haematological Malignancies: Prospective Nationwide Survey Subset Analysis in Japan. In Vivo 33(4):1355-1362, Jul-Aug, 2019 (doi: 10.21873/invivo.11611.)
・Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, Holt RA, Steidl C, Karsan A, Humphries RK, Eaves CJ, Hirst M, Weng AP. Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia. Nat Commun 10(1):2913, Jul 2, 2019 (doi: 10.1038/s41467-019-10510-8. 9
・Yamazaki H, Ohta K, Iida H, Imada K, Obara N, Tokumine Y, Tomiyama Y, Usuki K, Imajo K, Miyamura K, Sasaki O, Fanghong Z, Hattori T, Tajima T, Matsuda A, Nakao S. Hematologic recovery induced by eltrombopag in Japanese patients with aplastic anemia refractory or intolerant to immunosuppressive therapy. Int J Hematol 110(2):187-196, Aug, 2019 (doi: 10.1007/s12185-019-02683-1.) Epub Jun 10, 2019
・Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H, Zhao L, Ochi Y, Takeuchi Y, Takeda J, Ueno H, Kogure Y, Shiozawa Y, Kakiuchi N, Yoshizato T, Nakagawa MM, Nanya Y, Yoshida K, Makishima H, Sanada M, Sakata-Yanagimoto M, Chiba S, Matsuoka R, Noguchi M, Hiramoto N, Ishikawa T, Kitagawa J, Nakamura N, Tsurumi H, Miyazaki T, Kito Y, Miyano S, Shimoda K, Takeuchi K, Ohshima K, Yoshino T, Ogawa S, Kataoka K. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia 33(12):2867-2883, Dec, 2019 (doi: 10.1038/s41375-019-0473-1.) Epub May 15, 2019
・Sakamoto T, Obara N, Nishikii H, Kato T, Luan CS, Fujimura R, Yagita H, Sakata-Yanagimoto M, Takahashi S, Chiba S. Notch signaling in Nestin-expressing cells in the bone marrow maintains erythropoiesis via macrophage integrity. Stem Cells 37(7):924-936, Jul, 2019 (doi: 10.1002/stem.3011. ) Epub Apr 15, 2019
・Nishikii H, Kurita N, Shinagawa A, Sakamoto T, Kusakabe M, Yokoyama Y, Kato T, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Nakamura N, Chiba S. Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. Case Rep Hematol 2019:9710790, Jan 3, 2019 (doi: 10.1155/2019/9710790.) eCollection 2019.
・Cao-Sy L, Obara N, Sakamoto T, Kato T, Hattori K, Sakashita S, Nannya Y, Ogawa S, Harada H, Sakata-Yanagimoto M, Nishikii H, Chiba S. Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis. Int J Hematol 109(3):309-318, Mar, 2019 (doi: 10.1007/s12185-018-02576-9.) Epub Jan 10, 2019
・Tomiyama S, Sakata‐Yanagimoto M, Chiba S, Aikawa N. Development of automatic classification system for leukocyte images using Random Forest. Electronics and Communications in Japan 138(4):347–351, Aug 28, 2018 (doi: doi.org/10.1002/ecj.12113)
・Itonaga H, Ota S, Ikeda T, Taji H, Amano I, Hasegawa Y, Ichinohe T, Fukuda T, Atsuta Y, Tanizawa A, Kondo T, Miyazaki Y. Allogeneic hematopoietic stem cell transplantation for the treatment of BCR-ABL1-negative atypical chronic myeloid leukemia and chronic neutrophil leukemia: A retrospective nationwide study in Japan. Leuk Res 75:50-57, Dec, 2018 (doi: 10.1016/j.leukres.2018.11.003.) Epub Nov 13, 2018
・Kurita N, Sakamoto T, Kato T, Kusakabe M, Yokoyama Y, Nishikii H, Sakata-Yanagimoto M, Obara N, Hasegawa Y, Chiba S. The prognosis of disseminated intravascular coagulation associated with hematologic malignancy and its response to recombinant human thrombomodulin. Thromb Res 173:57-64, Jan, 2019 (doi: 10.1016/j.thromres.2018.11.014.) Epub Nov 16, 2018
・Miki K, Obara N, Makishima K, Sakamoto T, Kusakabe M, Kato T, Kurita N, Nishikii H, Yokoyama Y, Sakata-Yanagimoto M, Hasegawa Y, Chiba S. An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature. Case Rep Hematol 2018:7863943, Oct 10, 2018 (doi: 10.1155/2018/7863943.) eCollection 2018.
・Hattori K, Sakata-Yanagimoto M, Kusakabe M, Nanmoku T, Suehara Y, Matsuoka R, Noguchi M, Yokoyama Y, Kato T, Kurita N, Nishikii H, Obara N, Takano S, Ishikawa E, Matsumura A, Muratani M, Hasegawa Y, Chiba S. Genetic evidence implies that the primary and relapsed tumors arise from common precursor cells in primary CNS lymphoma. Cancer Sci 110(1):401-407, Jan, 2019 (doi: 10.1111/cas.13848.) Epub Oct 24, 2018
・Makishima K, Obara N, Ishitsuka K, Sukegawa S, Suma S, Kiyoki Y, Baba N, Sakamoto T, Kato T, Kusakabe M, Nishikii H, Kurita N, Yokoyama Y, Sakata-Yanagimoto M, Hasegawa Y, Chiba S. High efficacy of eculizumab treatment for fulminant hemolytic anemia in primary cold agglutinin disease. Ann Hematol 98(4):1031-1032, Apr, 2019 (doi: 10.1007/s00277-018-3521-4.) Epub Oct 15, 2018
・Fujiwara SI, Fujishima N, Kanamori H, Ito M, Sugimoto T, Saito S, Sakaguchi T, Nagai K, Masuoka H, Nagai K, Morita A, Kino S, Tanaka A, Hasegawa Y, Yokohama A, Fujino K, Makino S, Matsumoto M, Takeshita A, Muroi K. Released washed platelet concentrates are effective and safe in patients with a history of transfusion reactions. Transfus Apher Sci 57(6):746-751, Dec, 2018 (doi: 10.1016/j.transci.2018.09.001.) Epub Sep 7, 2018
・Yamada E, Ishikawa E, Watanabe R, Matsumura H, Sakamoto N, Ishii A, Tamaoka A, Hattori K, Obara N, Chiba S, Nakamagoe K, Matsuda M, Tsurubuchi T, Tomidokoro Y, Akutsu H, Zaboronok A, Shibuya M, Takano S, Matsumura A. Random skin biopsies prior to brain biopsy for intravascular large B-cell lymphoma. World Neurosurg 121:e364-e369, Jan, 2019 (doi: 10.1016/j.wneu.2018.09.110.) Epub Sep 24, 2018
・Hara T, Akutsu H, Takano S, Kino H, Ishikawa E, Tanaka S, Miyamoto H, Sakamoto N, Hattori K, Sakata-Yanagimoto M, Chiba S, Hiyama T, Masumoto T, Matsumura A. Clinical and biological significance of adamantinomatous craniopharyngioma with CTNNB1 mutation. J Neurosurg 131(1):217–226, Jul, 2019 (doi: 10.3171/2018.3.JNS172528.) Epub 2018, Aug 3, 2018
・Hosokawa K, Sugimori C, Ishiyama K, Takamatsu H, Noji H, Shichishima T, Obara N, Chiba S, Ninomiya H, Shirasugi Y, Nakamura Y, Ando K, Ueda Y, Yonemura Y, Kawaguchi T, Nishimura JI, Kanakura Y, Nakao S. Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure. Ann Hematol 97(12):2289-2297, Dec, 2018 (doi: 10.1007/s00277-018-3443-1.) Epub Jul 24, 2018
・Ueda Y, Obara N, Yonemura Y, Noji H, Masuko M, Seki Y, Wada K, Matsuda T, Akiyama H, Ikezoe T, Chiba S, Kanda Y, Kawaguchi T, Shichishima T, Nakakuma H, Okamoto S, Nishimura JI, Kanakura Y, Ninomiya H. Correction to: Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan. Int J Hematol 108(2):233-235, Aug, 2018 (doi: 10.1007/s12185-018-2486-3.) Epub Jul 6, 2018
・Matsuda A, Kawabata H, Tohyama K, Maeda T, Araseki K, Hata T, Suzuki T, Kayano H, Shimbo K, Usuki K, Chiba S, Ishikawa T, Arima N, Nohgawa M, Ohta A, Miyazaki Y, Nakao S, Ozawa K, Arai S, Kurokawa M, Mitani K, Takaori-Kondo A; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes. Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study. Leuk Res 74(2018):137-143, Nov, 2018 (doi: 10.1016/j.leukres.2018.06.003.) Epub Jun 7, 2018
・Suma S, Sakata-Yanagimoto M, Nguyen TB, Hattori K, Sato T, Noguchi M, Nannya Y, Ogawa S, Watanabe R, Fujimoto M, Nakamura N, Kusakabe M, Nishikii H, Kato T, Chiba S. Blastic plasmacytoid dendritic cell neoplasm arising from clonal hematopoiesis. Int J Hematol. Apr 28, 2018 (doi: 10.1007/s12185-018-2461-z.)
・Oya K, Watanabe R, Inoue S, Obara N, Kiyoki Y, Sakata-Yanagimoto M, Chiba S, Saito C, Matsumura Y, Nakamura Y, Ishitsuka Y, Maruyama H, Okiyama N, Fujisawa Y, Fujimoto M. Bullous pemphigoid accompanied by IgA nephropathy and atypical haemolytic uraemic syndrome. Eur J Dermatol Apr 5, 2018 (doi: 10.1684/ejd.2018.3285.)
・Kawajiri-Manako C, Sakaida E, Ohwada C, Miyamoto T, Azuma T, Taguchi J, Mori T, Hasegawa Y, Kondo T, Yujiri T, Yoshimitsu M, Imada K, Kurahashi S, Kahata K, Ichinohe T, Hirokawa M, Atsuta Y, Nakaseko C. Efficacy and Long-Term Outcomes of Autologous Stem Cell Transplantation in POEMS Syndrome: A Nationwide Survey in Japan. Biol Blood Marrow Transplant 24(6):1180-1186, Jun, 2018 (doi: 10.1016/j.bbmt.2018.01.026.) Epub Feb 1, 2018
・Abdelmoez MN, Iida K, Oguchi Y, Nishikii H, Yokokawa R, Kotera H, Uemura S, Santiago JG, Shintaku H. SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology. Genome Biol 19(1):66, Jun 6, 2018 (doi: 10.1186/s13059-018-1446-9.)
・Tanzima Nuhat S, Sakata-Yanagimoto M, Komori D, Hattori K, Suehara Y, Fukumoto K, Fujisawa M, Kusakabe M, Matsue K, Wakamatsu H, Shimadzu M, Chiba S. Droplet digital PCR assay and PNA-LNA clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma. Cancer Sci Mar 1, 2018 (doi: 10.1111/cas.13557.)
・Suehara Y, Sakata-Yanagimoto M, Hattori K, Nanmoku T, Itoh T, Kaji D,
Yamamoto G, Abe Y, Narita K, Takeuchi M, Matsue K, Sato T, Noguchi M, Baba
N, Sakamoto T, Kusakabe M, Kurita N, Kato T, Yokoyama Y, Nishikii H, Obara N,
Hasegawa Y, Chiba S. Liquid biopsy for the identification of intravascular large
B-cell lymphoma. Haematologica. (doi: 10.3324/haematol.2017.178830.)
[Epub ahead of print]
・Najima Y, Yoshida C, Iriyama N, Fujisawa S, Wakita H, Chiba S, Okamoto S, Kawakami K, Takezako N, Kumagai T, Ohyashiki K, Taguchi J, Yano S, Igarashi T, Kouzai Y, Morita S, Sakamoto J, Sakamaki H, Inokuchi K. Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response-The final results of the D-first study. Leuk Res 66(2018):66-72, Mar, 2018 (doi: 10.1016/j.leukres.2018.01.010.) Epub Feb 2, 2018
・Ueda Y, Obara N, Yonemura Y, Noji H, Masuko M, Seki Y, Wada K, Matsuda T, Akiyama H, Ikezoe T, Chiba S, Kanda Y, Kawaguchi T, Shichishima T, Nakakuma H, Okamoto S, Nishimura JI, Kanakura Y, Ninomiya H. Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan. Int J Hematol Jan 30, 2018 (doi: 10.1007/s12185-018-2409-3.) [Epub ahead of print]
・Maie K, Yokoyama Y, Yano Y, Kato T, Nannya Y, Ogawa S, Noguchi M, Sakata-
Yanagimoto M, Chiba S. Progression to polythythemia vera from familial
thrombocytosis with germline JAK2 R867Q mutation. Ann Hematol 97(4):737-
739, Apr, 2018 (doi: 10.1007/s00277-017-3209-1.) Epub, Jan 24, 2018
・Fujisawa M, Sakata-Yanagimoto M, Nishizawa S, Komori D, Gershon P, Kiryu M, Tanzima S, Fukumoto K, Enami T, Muratani M, Yoshida K, Ogawa S, Matsue K, Nakamura N, Takeuchi K, Izutsu K, Fujimoto K, Teshima T, Miyoshi H, Gaulard P, Ohshima K, Chiba S. Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma. Leukemia. 2017 (doi: 10.1038/leu.2017.273.) [Epub ahead of print]
・Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS. Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis. Nat Commun. 8:15068, 2017
・Nguyen TB, Sakata-Yanagimoto M, Asabe Y, Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyano H, Ohshima K, Minowa T, Ogawa S, Noguchi M, Chiba S. Identification of cell-type-specific mutations in nodal T-cell lymphomas. Blood Cancer J. 7:e516, 2017
・Makishima H, Yoshizato T, Yoshida K, Sekeres MA, Radivoyevitch T, Suzuki H, Przychodzen B, Nagata Y, Meggendorfer M, Sanada M, Okuno Y, Hirsch C, Kuzmanovic T, Sato Y, Sato-Otsubo A, LaFramboise T, Hosono N, Shiraishi Y, Chiba K, Haferlach C, Kern W, Tanaka H, Shiozawa Y, Gómez-Seguí I, Husseinzadeh HD, Thota S, Guinta KM, Dienes B, Nakamaki T, Miyawaki S, Saunthararajah Y, Chiba S, Miyano S, Shih LY, Haferlach T, Ogawa S, Maciejewski JP. Dynamics of clonal evolution in myelodysplastic syndromes. Nat Genet. 49(2):204-12, 2017
・Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS. DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft versus host disease. Blood. 128(24):2846-58, 2016
・Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S. Variegated RHOA mutations in adult T-cell leukemia/lymphoma. Blood. 127(5):596-604, 2016
・Nishikii H, Kanazawa Y, Umemoto T, Goltsev Y, Matsuzaki Y, Matsushita K, Yamato M, Nolan GP, Negrin R, Chiba S. Unipotent megakaryopoietic pathway bridging hematopoietic stem cells and mature megakaryocytes. Stem Cells. 33(7):2196-207, 2015
・Kasenda B, Ferreri AJ, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay JY, Hoang-Xuan K, Pulczynski EJ, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill BP, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor TT, Illerhaus G, Briel M. First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) - A Systematic Review and Individual Patient Data Meta-Analysis. Ann Oncol. 26(7):1305-13, 2015
・Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. Leukemia. 29(3):576-85, 2015
・Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchiba K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S. Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice. Blood Cancer J. 4:e264, 2014
・Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y, Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K, Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K, Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet. 46(2):171-5, 2014
・Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 478(7367):64-9, 2011
・Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood. 117(1):128-34, 2011
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当施設における造血幹細胞移植の成績
急性骨髄性白血病（2015～2022年，病期別）
縦軸，生存率；横軸，移植後年
急性リンパ性白血病（2015～2022年）
縦軸，生存率；横軸，移植後年
骨髄異形成症候群（2015～2022年）
縦軸，生存率；横軸，移植後年
非ホジキンリンパ腫（2015～2022年）
縦軸，生存率；横軸，移植後年
再生不良性貧血（2010～2020年）
縦軸，生存率；横軸，移植後年
研究業績
2012年度
- Kamada Y, Sakata-Yanagimoto M, Sanada M, Sato-Otsubo A, Enami T, Suzukawa K, Kurita N, Nishikii H, Yokoyama Y, Okoshi Y, Hasegawa Y, Ogawa S, Chiba S. Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis. Int J Hematol 96(4):492-500, Oct 2012.
- Nakamoto-Matsubara R, Nishikii H, Yamada K, Ito M, Hasegawa Y, Kurita N, Obara N, Okoshi Y, Suzukawa K, Yokoyama Y, Sakata-Yanagimoto M, Noguchi M, Chiba S. Early Pathologic Findings of Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: A Proposal from a Case. Case Report Hematol Epub Aug 22, 2012. (doi:10.1155/2012/957612)
- Sakata-Yanagimoto M, Chiba S. Notch2 and Immune Function. Curr Top Microbiol Immunol 360:151-61, 2012.
- Machino T, Okoshi Y, Miyake Y, Akatsuka Y, Chiba S. HLA-C Matching Status Does Not Affect Rituximab-Mediated Antibody-Dependent Cellular Cytotoxicity by Allogeneic Natural Killer Cells. Immunol Invest Posted online on June 8, 2012. (doi:10.3109/08820139.2012.691148)
- Yokoyama Y, Suzukawa K, Okoshi Y, Nanmoku T, Obara N, Enami T, Hasegawa Y, Chiba S. Nine years interval between first and second bone marrow transplantations and subsequent long-term survival-a case of acute myeloid leukemia with MLL-AF6 fusion gene. Ann Hematol 91(9):1491-3, Sep, 2012.
- Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H. Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther 14(2):R45, Published online Mar 5, 2012. (doi:10.1186/ar3758)
- Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoka K, Chiba S, Shimada M, Yasutomo K. Notch2 regulates the development of marginal zone B cells through Fos. Biochem Biophys Res Commun 418(4):701-717, Feb 24, 2012.
2011年度
- Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K. Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience 195:9-20, Nov 10, 2011.
- Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S. Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol: a single center retrospective analysis. J Clin Exp Hematol 51(2)109-114, Nov, 2011
- Goto M, Onizawa K, Yanagawa T, Yamagata K, Shinozuka K, Nishikii H, Koganemaru H, Chiba S, Bukawa H. Human Immunodeficiency Virus-Associated Burkitt's Lymphoma in Oral Cavity of Japanese Patient. J Oral Maxillofac Surg Nov, 10, 2011 [Epub ahead of print]
- Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature 478(7367):64-9, Oct 6, 2011
- Feng L, Eisenstat DD, Chiba S, Ishizaki Y, Gan L, Shibasaki K. Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience 195:9-20, 2011
- Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, Takahashi S. c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver. Blood 118(5):1374-85, Aug 4, 2011
- Sakurai N, Maeda M, Li M, Lee S-UK, Ishikawa Y, Williams JC, Wang L, Su L, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T. Notch-dependent and -independent regulation of mature B cell lineage fate and humoral immune response by the LRF transcription factor homodimer. J Clin Invest, 121(7):2583-98, Jul 1, 2011
- Nakano-Yokomizo T, Tahara-Hanaoka S, Nakahashi-Oda C, Nabekura T, Tchao NK, Kadosaki M, Totsuka N, Kurita N, Nakamagoe K, Tamaoka A, Takai T, Yasui T, Kikutani H, Honda S, Shibuya K, Lanier LL, Shibuya A. The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 208(8):1661-71, Aug 1, 2011
- Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H. Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. Br J Hematol 152（5）:631-639, Mar, 2011
- Yoshida C, Komeno T, Hori M, Kimura T, Fujii M, Okoshi Y, Suzukawa K, Chiba S, Hasegawa Y, Mukai HY, Ito T, Shimizu S, Kamoshita M, Kudo D, Shinagawa A, Chikatsu N, Monma Y, Watanabe N, Kojima H. Adherence to the standard dose of imatinib, rather than dose adjustment based on its plasma concentration, is critical to achieve a deep molecular response in patients with chronic myeloid leukemia. Int J Hematol 93(5):618-623, May, 2011
- Kurita N, Nishikii H, Nakamoto R, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Noguchi M, Chiba S. A highly therapy-resistant case with "B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma" showing strong BCL2 staining, otherwise indistinguishable from Burkitt lymphoma. J Clinical Experimental Hematothology 51(1):37-42, Ｍａｙ, 2011
- Kurita N, Okoshi Y, Nakamoto R, Sakamoto T, Suzukawa K, Hasegawa Y, Chiba S. Life saving treatment using amphotericin B liposome for a case with fungal meningitis due to orbital cellulitis. Jpn J Antibiot. 64(1):47-8 Feb,2011. Japanese. No abstract available.
- Yamagata K, Onizawa K, Yanagawa T, Takeuchi Y, Hasegawa Y, Chiba S, Bukawa H. Prospective study establishing a management plan for impacted third molar in patients undergoing hematopoietic stem cell transplantation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111(2):146-152, Feb, 2011
- Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117(1);128-134, Jan 6, 2011
- Kamada Y, Suzukawa K, Taoka K, Okoshi Y, Hasegawa Y, Chiba S. Relapse of acute meyloid leukemia with t(16;21)(p11;q22)mimicking autoimmune pancreatitis after second allogeneic bone marrow transplantation. ISRN Hematology 2011:285487, 2011
2010年度
- Taoka K, Okoshi Y, Sakamoto N, Takano S, Matsumura A, Hasegawa Y, Chiba S. A nonradiation-containing, intermediate-dose methotrexate regimen for elderly patients with primary central nervous system lymphoma. Int J Hematol 92(4):617-623, Nov, 2010
- Kurosawa S, Yamaguchi T, Miyawaki S, Uchida N, Sakura T, Kanamori H, Usuki K, Yamashita T, Okoshi Y, Shibayama H, Nakamae H, Mawatari M, Hatanaka K, Sunami K, Shimoyama M, Fujishima N, Maeda Y, Miura I, Takaue Y, Fukuda T. Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse. Haematologica 95(11):1857-1864, Nov, 2010
- Miyake Y, Okoshi Y, Machino T, Chiba S. Treatment of central nervous system lymphoma in rats with intraventricular rituximab and serum. Int J Hematol 92(3):474-480, Oct, 2010
- Doki K, Homma M, Hori T, Tomita T, Hasegawa Y, Ito S, Fukunaga K, Kaneko M, Chiba S, Sumida T, Ohkohchi N, Kohda Y. Difference in blood tacrolimus concentration between ACMIA and MEIA in samples with low haematocrit values. J Pharm Pharmacol 62(9):1185-1188, Oct, 2010
- Sugumito K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K. Notch2 signaling is required for potent anti-tumor immunity in vivo. J Immunol 184(9):4673-4678, May 1, 2010
- Muto H, Ohashi H, Ando M, Akiyama H, Sakamaki H. Cystatin C level as a marker of renal function in allogeneic hematopoietic stem cell transplantation. Int J Hematol 91(3):471-477, Apr, 2010
- Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood 115(14):2872-2881, Apr 8, 2010
- Okada S, Nannya Y, Ota S, Takazawa Y, Yamamoto G, Kumano K, Izutsu K, Takahashi T, Chiba S, Kurokawa M. Cutaneous T-cell lymphoma (mycosis fungoides) relapsed with different immunological phenotype after bone marrow transplant. Br J Dermatol 162(1):229-230, Jan, 2010
- Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120(1):179-190, Jan, 2010
- Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H. Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol 32:e137-e143, Jan, 2010
2009年度
- Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H. Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol 32(1 Pt 1):e137-143, Feb, 2010
- Koshino M, Kudou D, Okoshi Y, Obara N, Simizu S, Mukai HY, Suzukawa K, Hasegawa Y, Kojima H, Nagasawa T, Chiba S. Successful treatment with rituximab in a patient with refractory thrombotic thrombocytopenic purpura refractory to plasma exchange. Rinsho Ketsueki 51(2):127-131, Feb, 2010
- Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest 120(1):179-190, Jan 4, 2010
- Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S. Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model. Cancer Sci 100(12):2444-2450, Dec, 2009
- Matsumoto K, Obara N, Ema M, Horie M, Naka A, Takahashi S, Imagawa S. Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model. Cancer Sci 100(9):1639-1647, Sep, 2009
- Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 460(7257):904-908, Aug 13, 2009
- Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Proc Natl Acad Sci U S A 106(27):11230-11235, Jul 7, 2009
- Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S. Derivation of functional mature neutrophils from human embryonic stem cells. Blood 113(26):6584-6592, Jun 25, 2009
- Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S. Frequent inactivation of A20 in B-cell lymphomas. Nature 459(7247):712-716, Jun 4, 2009
- Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S. Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. J Immunol 182(10):6168-6178, May 15, 2009
- Lee SY, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto G, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S. Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci 100(5):920-926, May, 2009
2008年度
- Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K. Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells. J Immunol 182(6):3566-3572, Mar, 2009
- Kurita N, Honda S, Usui K, Shimizu Y, Miyamoto A, Tahara-Hanaoka S, Shibuya K, Shibuya A. Identification of the Fcalpha/muR isoform specifically expressed in the kidney tubules. Mol Immunol 46(4):749-753, Feb, 2009
- Kataoka K, Nannya Y, Hangaishi A, Imai Y, Chiba S, Takahashi T, Kurokawa M. Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15(2):195-204, Feb, 2009
- Ishigaki T, Sudo K, Hiroyama T, Miharada K, Ninomiya H, Chiba S, Nagasawa T, Nakamura Y. Human hematopoietic stem cells can survive in vitro for several months. Adv Hematol 2009(936761), 2009
- Ogawa S, Matsubara A, Onizuka M, Kashiwase K, Sanada M, Kato M, Nannya Y, Akatsuka Y, Satake M, Takita J, Chiba S, Saji H, Maruya E, Inoko H, Morishima Y, Kodera Y, Sasazuki T. Japan Marrow Donation Program (JMDP). Exploration of the genetic basis of GVHD by genetic association studies. Biol Blood Marrow Transplant. 2009 Jan;15(1 Suppl):39-41. No abstract available.
- Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K. Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol 123(1):74-81, Jan, 2009.
- Kanda Y, Okamoto S, Tauchi T, Kizaki M, Inokuchi K, Yabe M, Yokoyama K, Ito Y, Kimura Y, Higashihara M, Bessho M, Ando K, Chiba S, Kurokawa M, Oshimi K, Dan K, Ohyashiki K, Ikeda Y; for the Tokyo STI Study Group (TSSG). Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: Does body weight matter? Am J Hematol. 2008 Nov;83(11):835-839.
- Nakagawa K, Kanda Y, Yamashita H, Nakagawa S, Sasano N, Ohtomo K, Oshima K, Kumano K, Ban N, Minamitani Y, Kurokawa M, Chiba S. Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. Bone Marrow Transplant. 2008 Nov;42(10):697-699.
- Oshima K, Kanda Y, Kako S, Asano-Mori Y, Watanabe T, Motokura T, Chiba S, Shiraki K, Kurokawa M. Case report: persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes. J Med Virol. 2008 Oct;80(10):1769-1775.
- Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto S, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K. Notch 2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol. 2008 Oct;9(10):1140-1147.
- Goyama S, Yamamoto G, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell. 2008 Aug;3(2):207-220.
- Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M. AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. Leukemia. 2008 Jun;22(6):1241-1249.
- Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, Hirose S, Okumura K, Yagita H. Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol. 2008 Jun:20(6):763-773.
- Yoshimi A, Izutsu K, Takahashi M, Kako S, Oshima K, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, Kurokawa M. Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation. Am J Hematol. 2008 Jun;83(6):477-481.
- Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M. Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2008 Jun;83(3);472-476.
- Tomita T, Homma M, Hasegawa Y, Kojima H, Ohkohchi N, Hori T, Kaneko M, Nakano Y, Tobe T, Kohda Y. Use of sample hematocrit value to correct blood tacrolimus concentration derived by microparticle enzyme immunoassay. Biol Pharm Bull. 2008 Jun;31(6):1250-3.
- Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S. Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7839-44.
- Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K. Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction. Proc Natl Acad Sci USA. 2008 May;105(19):7010-7015.
- Kusakabe M, Suzukawa K, Nanmoku T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Ninomiya H, Nagasawa T. Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding. Eur J Haematol. 2008 May;80(5):444-7.
- Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008 May 15;111(10):5223-32.
- Yoshimi A, Nannya Y, Sakata-Yanagimoto M, Oshima K, Takahashi T, Kanda Y, Motokura T, Chiba S, Kurokawa M. A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: Reduced cyclophosphamide combined with etoposide and total body irradiation. Am J Hematol. 2008 Apr;83(8):635-639.
- Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M. Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Int J Hematol. 2008 Apr; 87(3):310-318.
- Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 2008 Apr 15;22(8):986-991.
- Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M. AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis. J Immunol. 2008 Apr 1;180(7):4402-4408.
2007年度
- Ishii W, Ito S, Kondo Y, Tsuboi H, Mamura M, Goto D, Matsumoto I, Tsutsumi A, Sumida T, Okoshi Y, Hasegawa Y, Kojima H, Sakashita S, Aita K, Noguchi M. Intravascular large B-cell lymphoma with acute abdomen as a presenting symptom in a patient with systemic lupus erythematosus. J Clin Oncol. 2008 Mar 20;26(9):1553-5.
- Homma M, Inoue Y, Hasegawa Y, Kojima H, Kohda Y. Blood ribavirin concentration in high-dose ribavirin for adenovirus-induced haemorrhagic cystitis - a case report. J Clin Pharm Ther. 2008 Feb;33(1):75-8.
- Ninomiya H, Sato S, Hasegawa Y, Nagasawa T. Shortened lifespan of paroxysmal nocturnal haemoglobinuria-affected RBC estimated from differences in ratios of CD59-negative populations between reticulocytes and whole RBC. Int J Lab Hematol. 2008 Feb;30(1):41-5.
- Suzuki N, Obara N, Yamamoto M. Use of gene-manipulated mice in the study of erythropoietin gene expression. Methods Enzymol. 2007 Nov;435:157-77.
- Katsura Y, Suzukawa K, Nanmoku T, Nemoto N, Machino T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Nagasawa T. Myelodysplastic syndrome accompanied by basophilia and eosinophilia with t(5;12)(q31;p13). Cancer Genet Cytogenet. 2007 Oct 1;178(1):85-8.
- Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer. 2007 Sep;46(9):813-9.
- Fu L, Isobe K, Zeng Q, Suzukawa K, Takekoshi K, Kawakami Y. beta-adrenoceptor agonists downregulate adiponectin, but upregulate adiponectin receptor 2 and tumor necrosis factor-alpha expression in adipocytes. Eur J Pharmacol. 2007 Aug 13;569(1-2):155-62.
- Bonini C, Bondanza A, Perna SK, Kaneko S, Traversari C, Ciceri F, Bordignon C. The suicide gene therapy challenge: how to improve a successful gene therapy approach. Mol Ther. 2007 Jul;15(7):1248-52.
- Kozuma Y, Kojima H, Yuki S, Suzuki H, Nagasawa T. Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. J Thromb Haemost. 2007 Jun;5(6):1274-82.
- Machino T, Okoshi Y, Kaneko S, Obara N, Mukai HY, Suzukawa K, Hasegawa Y, Yamashita Y, Mori N, Kojima H, Nagasawa T. Hepatosplenic alphabeta T-cell lymphoma successfully treated with allogeneic bone marrow transplantation. Bone Marrow Transplant. 2007 Apr;39(8):513-4.
2006年度
- Sugita S, Iijima T, Furuya S, Kano J, Yanaka A, Ohta K, Kojima H, Noguchi M. Gastric T-cell lymphoma with cytotoxic phenotype. Pathol Int. 2007 Feb;57(2):108-14.
- Isobe K, Minowada S, Tatsuno I, Suzukawa K, Nissato S, Nanmoku T, Hara H, Yashiro T, Kawakami Y, Takekoshi K. Novel germline mutations in the SDHB and SDHD genes in Japanese pheochromocytomas. Horm Res. 2007 Feb;68(2):68-71.
- Sunada K, Hasegawa Y, Kodama T, Anami Y, Satoh H, Ohtsuka M, Sekizawa K. Thymic and pulmonary mucosa-associated lymphoid tissue lymphomas in a patient with Sjogren's syndrome and literature review. Respirology. 2007 Jan;12(1):144-7.
- Nakahashi C, Tahara-Hanaoka S, Totsuka N, Okoshi Y, Takai T, Ohkohchi N, Honda S, Shibuya K, Shibuya A. Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol. 2007 Jan 15;178(2):765-70.
- Muto H, Kaneko S, Machino T, Okoshi Y, Mukai HY, Suzukawa K, Hasegawa Y, Imagawa S, Kojima H, Ishii Y, Hitomi S, Nagasawa T. Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma. J Infect Chemother 2006 Dec;12:391-395.
- Kojima H, Moroi M, Jung SM, Goto S, Tamura N, Kozuma Y, Suzukawa K, Nagasawa T. Characterization of a patient with glycoprotein(GP) VI deficiency possessing neither anti-GPVI autoantibody nor genetic aberration. Journal of Thrombosis and Haemostasis 2006 Nov;4:2433-2442.
- Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells. Nature Biotechnology 2006 Oct;24(10):1255-1256.
- Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, Nomura S, Kojima T, Yagi H, Ikeda Y. Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study. Journal of Thrombosis and Haemostasis 2006 Sep;4:1936-1943.
- Nitta T, Kanai M, Sugihara E, Tanaka M, Sun B, Nagasawa T, Sonoda S, Saya H, Miwa M. Centrosome amplification I adult T-cell leukemia and human T-cell leukemia virus type 1 Tax-induced human T cells. Cancer Science 2006 Sep;97(9):836-841.
- Kojima H, Katsuoka Y, Katsura Y, Suzuki S, Suzukawa K, Hasegawa Y, Nagasawa T. Successful treatment of a patient with POEMS syndrome by tandem high-dose chemotherapy with autologous CD34+ purged stem cell rescue. International Journal of Hematology 2006 Aug;84:182-185.
- Yamagata K, Onizawa K, Yanagawa T, Hasegawa Y, Kojima H, Nagasawa T, Yoshida H. A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation. Bone Marrow Transplantation 2006 Aug;38:237-242.
- Sato S, Hasegawa Y, Nagasawa T, Ninomiya H. Reticulocyte-gated flow cytometric analysis of red blood cells in paroxysmal nocturnal hemoglobinuria. Laboratory Hematology 2006 Jun;12(2):82-85.
2005年度以前
- Nabekura, T., M. Otsu, T. Nagasawa, H. Nakauchi, and M. Onodera, Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap. Mol Ther, 2006 Feb. 13(2): p. 301-9.
- Miharada K, Hiroyama T, Sudo K, Nagasawa T, Nakamura Y. Refinement of cytokine use in the in vitro expansion of erythroid cells. Human cell 2006 Feb;19(1):30-37.
- Tomita, T., M. Homma, K. Yuzawa, N. Ohkohchi, T. Hori, M. Kaneko, Y. Hasegawa, H. Kojima, T. Nagasawa, and Y. Kohda, Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring. Ther Drug Monit, 2005. 27(1): p. 94-7.
- Suzukawa, K., S. Shimizu, N. Nemoto, N. Takei, T. Taki, and T. Nagasawa, Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). Int J Hematol, 2005. 82(1): p. 38-41.
- Shinagawa, A., H. Kojima, M.C. Berndt, S. Kaneko, K. Suzukawa, Y. Hasegawa, O. Shigeta, and T. Nagasawa, Characterization of a myeloma patient with a life-threatening hemorrhagic diathesis: presence of a lambda dimer protein inhibiting shear-induced platelet aggregation by binding to the A1 domain of von Willebrand factor. Thromb Haemost, 2005. 93(5): p. 889-96.
- Shimizu, Y., K. Suzukawa, Y. Hirano, M. Seki, K. Hirayama, K. Yoh, A. Hirayama, K. Yamagata, S. Nagase, T. Nagasawa, and A. Koyama, Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome. Nephrology (Carlton), 2005. 10(2): p. 147-50.
- Okoshi, Y., S. Tahara-Hanaoka, C. Nakahashi, S. Honda, A. Miyamoto, H. Kojima, T. Nagasawa, K. Shibuya, and A. Shibuya, Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol, 2005. 17(1): p. 65-72.
- Kitamura, A., Y. Yamashita, Y. Sato, Y. Hasegawa, H. Kojima, T. Nagasawa, and N. Mori, Aggressive Lennert's lymphoma: report of three cases in comparison to non-aggressive Lennert's lymphoma. Pathol Int, 2005. 55(10): p. 626-31.
- Kitamura, A., Y. Yamashita, Y. Hasegawa, H. Kojima, T. Nagasawa, and N. Mori, Primary lymphoma arising in the nasal cavity among Japanese. Histopathology, 2005. 47(5): p. 523-32.
- Kaneko, S., T. Nagasawa, H. Nakauchi, and M. Onodera, An in vivo assay for retrovirally transduced human peripheral T lymphocytes using nonobese diabetic/severe combined immunodeficiency mice. Exp Hematol, 2005. 33(1): p. 35-41.
- Kaneko, S., M. Onodera, and T. Nagasawa, [Gene therapy for leukemia]. Nippon Rinsho, 2005. 63 Suppl 12: p. 637-40.
- Yoshida, C., K. Suzukawa, Y. Katsura, S. Shimizu, H.Y. Mukai, Y. Hasegawa, S. Imagawa, H. Kojima, and T. Nagasawa, T-cell acute lymphoblastic leukemia with add(1)(p36) and del(12)(p11) following acute myelocytic leukemia with partial deletion of 9p. Cancer Genet Cytogenet, 2004. 150(1): p. 62-5.
- Yoshida, C., H. Kojima, T. Iijima, Y. Katsura, S. Shimizu, K. Suzukawa, H.Y. Mukai, Y. Hasegawa, M. Abei, and T. Nagasawa, Association of non-alcoholic steatohepatitis (NASH) with chronic neutrophilic leukemia. Eur J Haematol, 2004. 72(3): p. 225-8.
- Yoshida, C., H. Kojima, T. Ishigaki, Y. Katsura, S. Kaneko, K. Suzukawa, Y. Hasegawa, Y. Kawachi, F. Otsuka, and T. Nagasawa, Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10). Eur J Haematol, 2004. 72(2): p. 149-53.
- Sato, S., K. Hirayama, A. Koyama, T. Harano, T. Nagasawa, and H. Ninomiya, Pseudoreticulocytosis in a patient with hemoglobin Koln due to autofluorescent erythrocytes enumerated as reticulocytes by the Cell-Dyn 4000. Lab Hematol, 2004. 10(2): p. 65-7.
- Nakano, Y., S. Imagawa, K. Matsumoto, C. Stockmann, N. Obara, N. Suzuki, T. Doi, T. Kodama, S. Takahashi, T. Nagasawa, and M. Yamamoto, Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. Blood, 2004. 104(13): p. 4300-7.
- Kojima, H., Y. Hasegawa, K. Suzukawa, H.Y. Mukai, S. Kaneko, T. Kobayashi, M. Kamoshita, A. Shinagawa, T. Komeno, T. Komatsu, S. Mitsuhashi, Y. Kawachi, Y. Yamashita, N. Mori, and T. Nagasawa, Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification. Leuk Res, 2004. 28(12): p. 1287-92.
- Imagawa, S., Y. Yamaguchi, K. Ogawa, N. Obara, N. Suzuki, M. Yamamoto, and T. Nagasawa, Interleukin-6 and tumor necrosis factor-alpha in patients with obstructive sleep apnea-hypopnea syndrome. Respiration, 2004. 71(1): p. 24-9.
- Hanai, S., T. Nitta, M. Shoda, M. Tanaka, N. Iso, I. Mizoguchi, S. Yashiki, S. Sonoda, Y. Hasegawa, T. Nagasawa, and M. Miwa, Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia. Cancer Sci, 2004. 95(4): p. 306-10.
- Shimizu, S., Y. Tamagawa, H. Kojima, N. Mori, M. Nagata, M. Noguchi, and T. Nagasawa, Simultaneous development of lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma--analyses of the clonal relatedness by sequencing CDR3 in immunoglobulin heavy chain genes. Eur J Haematol, 2003. 70(2): p. 119-24.
- Shimizu, S., H. Kojima, C. Yoshida, K. Suzukawa, H.Y. Mukai, Y. Hasegawa, S. Hitomi, and T. Nagasawa, Chorioamnionitis caused by Serratia marcescens in a non-immunocompromised host. J Clin Pathol, 2003. 56(11): p. 871-2.
- Obara, N., S. Imagawa, Y. Nakano, N. Suzuki, M. Yamamoto, and T. Nagasawa, Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2. Arch Toxicol, 2003. 77(5): p. 267-73.
- Obara, N., S. Imagawa, Y. Nakano, M. Yamamoto, T. Noguchi, and T. Nagasawa, Hematological aspects of a novel 9-aminoanthracycline, amrubicin. Cancer Sci, 2003. 94(12): p. 1104-6.
- Mukai, H.Y., Y. Okoshi, S. Shimizu, Y. Katsura, N. Takei, Y. Hasegawa, H. Kojima, N. Mori, and T. Nagasawa, Successful treatment of a patient with subcutaneous panniculitis-like T-cell lymphoma with high-dose chemotherapy and total body irradiation. Eur J Haematol, 2003. 70(6): p. 413-6.
- Kojima, H., N. Takei, Y. Mukai, Y. Hasegawa, K. Suzukawa, M. Nagata, M. Noguchi, N. Mori, and T. Nagasawa, Hemophagocytic syndrome as the primary clinical symptom of Hodgkin's disease. Ann Hematol, 2003. 82(1): p. 53-6.
- Kojima, H., H. Kanada, S. Shimizu, E. Kasama, K. Shibuya, H. Nakauchi, T. Nagasawa, and A. Shibuya, CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J Biol Chem, 2003. 278(38): p. 36748-53.
- Kojima, H., S. Shimizu, C. Yoshida, Y. Katsura, K. Suzukawa, H.Y. Mukai, Y. Hasgawa, S. Imagawa, N. Mori, and T. Nagasawa, Rapidly progressive Lennert's lymphoma terminating in fulminant hepatic failure. Leuk Lymphoma, 2003. 44(8): p. 1409-12
- Katsura, Y., K. Suzukawa, H. Kojima, C. Yoshida, S. Shimizu, H. Mukai, Y. Hasegawa, S. Imagawa, N. Mori, and T. Nagasawa, Cytotoxic T-cell lymphoma arising in Behcet disease. Int J Hematol, 2003. 77(3): p. 282-5.
- Imagawa, S., Y. Nakano, N. Obara, N. Suzuki, T. Doi, T. Kodama, T. Nagasawa, and M. Yamamoto, A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. Faseb J, 2003. 17(12): p. 1742-4.
- Horigome, H., T. Murakami, T. Isobe, T. Nagasawa, and A. Matsui, Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis. Thromb Res, 2003. 112(4): p. 223-7.
- Suzuki, A., Y.W. Zheng Yw, S. Kaneko, M. Onodera, K. Fukao, H. Nakauchi, and H. Taniguchi, Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol, 2002. 156(1): p. 173-84.
- Suzukawa, K., T.J. Weber, and N.H. Colburn, AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ Health Perspect, 2002. 110(9): p. 865-70.
- Suzukawa, K. and N.H. Colburn, AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers. Oncogene, 2002. 21(14): p. 2181-90.
- Sakai, Y., D.K. Kim, S. Iwasa, J. Liang, T. Watanabe, M. Onodera, and H. Nakauchi, Bone marrow chimerism prevents atherosclerosis in arterial walls of mice deficient in apolipoprotein E. Atherosclerosis, 2002. 161(1): p. 27-34.
- Osawa, M., T. Yamaguchi, Y. Nakamura, S. Kaneko, M. Onodera, K. Sawada, A. Jegalian, H. Wu, H. Nakauchi, and A. Iwama, Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood, 2002. 100(8): p. 2769-77.
- Okoshi, Y., S. Imagawa, M. Higuchi, C. Yoshida, S. Shimizu, H.Y. Mukai, T. Komeno, Y. Hasegawa, H. Ninomiya, H. Kojima, and T. Nagasawa, A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. Intern Med, 2002. 41(7): p. 589-92.
- Mukai, H.Y., Y. Hasegawa, H. Kojima, Y. Okoshi, N. Takei, Y. Yamashita, T. Nagasawa, and N. Mori, Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity. Mod Pathol, 2002. 15(11): p. 1131-9.
- Kojima, H., M. Abei, N. Takei, Y. Mukai, Y. Hasegawa, T. Iijima, and T. Nagasawa, Fatal reactivation of hepatitis B virus following cytotoxic chemotherapy for acute myelogenous leukemia: fibrosing cholestatic hepatitis. Eur J Haematol, 2002. 69(2): p. 101-4.
- Iwama, A., M. Osawa, R. Hirasawa, N. Uchiyama, S. Kaneko, M. Onodera, K. Shibuya, A. Shibuya, C. Vinson, D.G. Tenen, and H. Nakauchi, Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment. J Exp Med, 2002. 195(5): p. 547-58.
- Inoue, H., G. Kawano, H. Nagasawa, and S. Sakuda, Isolation of elemental sulfur as a self-growth-inhibiting substance produced by Legionella pneumophila. Appl Environ Microbiol, 2002. 68(10): p. 4809-11.
- Imagawa, S., N. Suzuki, K. Ohmine, N. Obara, H.Y. Mukai, K. Ozawa, M. Yamamoto, and T. Nagasawa, GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter. Int J Hematol, 2002. 75(4): p. 376-81.
- Imagawa, S., T. Tarumoto, N. Suzuki, H.Y. Mukai, Y. Hasegawa, M. Higuchi, T. Neichi, K. Ozawa, M. Yamamoto, and T. Nagasawa, L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA. Kidney Int, 2002. 61(2): p. 396-404.
- Horigome, H., Y. Hiramatsu, O. Shigeta, T. Nagasawa, and A. Matsui, Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia. J Am Coll Cardiol, 2002. 39(6): p. 1072-7.
- Hirasawa, R., R. Shimizu, S. Takahashi, M. Osawa, S. Takayanagi, Y. Kato, M. Onodera, N. Minegishi, M. Yamamoto, K. Fukao, H. Taniguchi, H. Nakauchi, and A. Iwama, Essential and instructive roles of GATA factors in eosinophil development. J Exp Med, 2002. 195(11): p. 1379-86.
- Urasaki, T., J. Takasaki, T. Nagasawa, and H. Ninomiya, Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. J Leukoc Biol, 2001. 69(1): p. 105-12.
- Tabata, M., T. Tarumoto, K. Ohmine, Y. Furukawa, K. Hatake, K. Ozawa, Y. Hasegawa, H. Mukai, M. Yamamoto, and S. Imagawa, Stimulation of GATA-2 as a mechanism of hydrogen peroxide suppression in hypoxia-induced erythropoietin gene expression. J Cell Physiol, 2001. 186(2): p. 260-7.
- Shinagawa, A., H. Kojima, T. Kobayashi, K. Kawada, and T. Nagasawa, Lupus anticoagulant-like activity observed in a dimeric lambda protein produced by myeloma cells. Int J Hematol, 2001. 73(4): p. 526-31.
- Okoshi, Y., S. Shimizu, H. Kojima, N. Obara, H.Y. Mukai, T. Komeno, Y. Hasegawa, N. Mori, and T. Nagasawa, Detection of minimal residual disease in a patient having acute myelogenous leukemia with t(16;21)(p11;q22) treated by allogeneic bone marrow transplantation. Acta Haematol, 2001. 105(1): p. 45-8.
- Ohmine, K., J. Ota, M. Ueda, S. Ueno, K. Yoshida, Y. Yamashita, K. Kirito, S. Imagawa, Y. Nakamura, K. Saito, M. Akutsu, K. Mitani, Y. Kano, N. Komatsu, K. Ozawa, and H. Mano, Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells. Oncogene, 2001. 20(57): p. 8249-57.
- Miura, K., S. Miyazawa, S. Furuta, J. Mitsushita, K. Kamijo, H. Ishida, T. Miki, K. Suzukawa, J. Resau, T.D. Copeland, and T. Kamata, The Sos1-Rac1 signaling. Possible involvement of a vacuolar H(+)-ATPase E subunit. J Biol Chem, 2001. 276(49): p. 46276-83.
- Kojima, H., A. Shinagawa, S. Shimizu, H. Kanada, M. Hibi, T. Hirano, and T. Nagasawa, Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function. Exp Hematol, 2001. 29(5): p. 616-22.
- Kaneko, S., M. Onodera, Y. Fujiki, T. Nagasawa, and H. Nakauchi, Simplified retroviral vector gcsap with murine stem cell virus long terminal repeat allows high and continued expression of enhanced green fluorescent protein by human hematopoietic progenitors engrafted in nonobese diabetic/severe combined immunodeficient mice. Hum Gene Ther, 2001. 12(1): p. 35-44.
- Imagawa, S., Y. Yamaguchi, M. Higuchi, T. Neichi, Y. Hasegawa, H.Y. Mukai, N. Suzuki, M. Yamamoto, and T. Nagasawa, Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea--hypopnea syndrome. Blood, 2001. 98(4): p. 1255-7.
- Urasaki, T., J. Takasaki, T. Nagasawa, and H. Ninomiya, Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. Inflamm Res, 2000. 49(4): p. 177-83.
- Toshima, M., T. Nagai, T. Izumi, T. Tarumoto, M. Takatoku, S. Imagawa, N. Komatsu, and K. Ozawa, All-trans-retinoic acid treatment for chemotherapy-resistant acute adult T-cell leukemia. Int J Hematol, 2000. 72(3): p. 343-5.
- Tomobe, M., N. Miyanaga, K. Kawai, K. Kikuchi, K. Uchida, H. Takeshima, Y. Hasegawa, T. Nagasawa, and H. Akaza, [Intrascrotal tumors: a clinicopathologic study of 15 cases]. Nippon Hinyokika Gakkai Zasshi, 2000. 91(9): p. 618-22.
- Tarumoto, T., S. Imagawa, K. Ohmine, T. Nagai, M. Higuchi, N. Imai, N. Suzuki, M. Yamamoto, and K. Ozawa, N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2. Blood, 2000. 96(5): p. 1716-22.
- Tarumoto, T., S. Imagawa, K. Ohmine, A. Mano, T. Nagai, M. Takatoku, K. Muroi, K. Hatake, and K. Ozawa, A de novo philadelphia chromosome-positive acute mixed-lineage leukemia with both major and minor BCR/ABL mRNA transcripts. Am J Hematol, 2000. 65(1): p. 72-4.
- Tarumoto, T., S. Imagawa, T. Hotta, K. Ohmine, T. Nagai, M. Takatoku, N. Komatsu, K. Hatake, and K. Ozawa, A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia. Jpn J Clin Oncol, 2000. 30(3): p. 159-62.
- Tabata, M., S. Imagawa, T. Tarumoto, K. Ohmine, K. Hatake, Y. Miura, and K. Ozawa, Essential thrombocythemia transformed to acute myelogenous leukemia with t(3;17)(p24; q12), del(5)(q13q34) after treatment with carboquone and hydroxyurea. Jpn J Clin Oncol, 2000. 30(7): p. 310-2.
- Suzukawa, K., K. Miura, J. Mitsushita, J. Resau, K. Hirose, R. Crystal, and T. Kamata, Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem, 2000. 275(18): p. 13175-8.
- Suzukawa, K., M. Amoh, Y. Nakamura, Y. Yasuma, and S. Kurokawa, [Spontaneous occlusion of a dissecting aneurysm in the shape of "two dumplings on a skewer" at righ posterior inferior cerebellar artery (PICA): report of a case and neuroradiological findings]. No Shinkei Geka, 2000. 28(6): p. 561-7.
- Shimizu, S., K. Suzukawa, T. Kodera, T. Nagasawa, T. Abe, M. Taniwaki, F. Yagasaki, H. Tanaka, S. Fujisawa, B. Johansson, T. Ahlgren, J. Yokota, and K. Morishita, Identification of breakpoint cluster regions at 1p36.3 and 3q21 in hematologic malignancies with t(1;3)(p36;q21). Genes Chromosomes Cancer, 2000. 27(3): p. 229-38.
- Shimizu, K., I. Kitabayashi, N. Kamada, T. Abe, N. Maseki, K. Suzukawa, and M. Ohki, AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon. Blood, 2000. 96(1): p. 288-96.
- Ohmine, K., T. Izumi, K. Muroi, R. Shimizu, S. Imagawa, N. Komatsu, R. Sasaki, K. Hatake, Y. Miura, and K. Ozawa, [Low-dose prednisolone therapy for idiopathic thrombocytopenic purpura]. Rinsho Ketsueki, 2000. 41(1): p. 8-11.
- Nishimura, S., S. Takahashi, T. Kuroha, N. Suwabe, T. Nagasawa, C. Trainor, and M. Yamamoto, A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene. Mol Cell Biol, 2000. 20(2): p. 713-23.
- Ninomiya, H., Y. Kawashima, and T. Nagasawa, Inhibition of complement-mediated haemolysis in paroxysmal nocturnal haemoglobinuria by heparin or low-molecular weight heparin. Br J Haematol, 2000. 109(4): p. 875-81.
- Nagashima, T., T. Izumi, K. Muroi, A. Miyasato, M. Uchida, S. Imagawa, N. Komatsu, M. Yoshida, K. Hatake, Y. Miura, and K. Ozawa, [Two cases of acute myelogenous leukemia complicated with fatal gastrointestinal tract bleeding after treatment with idarubicin and cytarabine]. Gan To Kagaku Ryoho, 2000. 27(3): p. 487-90.
- Muroi, K., T. Suzuki, Y. Amemiya, M. Yoshida, C. Kawano, R. Kuribara, T. Otsuki, T. Izumi, H. Tomizuka, N. Komatsu, S. Imagawa, K. Hatake, Y. Miura, and K. Ozawa, Autologous peripheral blood stem cell transplantation for adults with B-lineage acute lymphoblastic leukemia: a pilot study. Leuk Lymphoma, 2000. 38(1-2): p. 103-11.
- Mukai, H.Y., H. Kojima, K. Suzukawa, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, Nasal natural killer cell lymphoma in a post-renal transplant patient. Transplantation, 2000. 69(7): p. 1501-3.
- Kojima, H., A. Bai, H.Y. Mukai, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, Chronic myelomonocytic leukemia derived from a possible common progenitor of monocytes and natural killer cells. Leuk Lymphoma, 2000. 37(5-6): p. 617-21.
- Kojima, H., H.Y. Mukai, A. Shinagawa, C. Yoshida, M. Kamoshita, T. Komeno, Y. Hasegawa, Y. Yamashita, N. Mori, and T. Nagasawa, Clinicopathological analyses of 5 Japanese patients with CD56+ primary cutaneous lymphomas. Int J Hematol, 2000. 72(4): p. 477-83.
- Kawashima, Y., T. Nagasawa, and H. Ninomiya, Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells. Blood, 2000. 96(6): p. 2157-62.
- Kamoshita, M. and T. Nagasawa, [Immune megakaryocytopenia]. Ryoikibetsu Shokogun Shirizu, 2000(31): p. 146-51.
- Ishii, M., M. Iwahana, I. Mitsui, M. Minami, S. Imagawa, A. Tohgo, and A. Ejima, Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. Anticancer Drugs, 2000. 11(5): p. 353-62.
- Ichida, M., S. Imagawa, K. Ohmine, N. Komatsu, K. Hatake, K. Ozawa, and Y. Miura, Successful treatment of multiple myeloma--associated amyloidosis by interferon-alpha, dimethyl sulfoxide, and VAD (vincristine, adriamycin, and dexamethasone). Int J Hematol, 2000. 72(4): p. 491-3.
- Hasegawa, Y., A. Bai, H. Kojima, T. Komeno, H. Ninomiya, and T. Nagasawa, Priming effects of macrophage colony-stimulating factor on monocytic leukemia cells in combination with chemotherapy: induction of programmed cell death in vivo. Leuk Lymphoma, 2000. 36(5-6): p. 589-93.
- Hasegawa, Y. and T. Nagasawa, [Thrombotic thrombocytopenic purpura]. Ryoikibetsu Shokogun Shirizu, 2000(31): p. 152-4.
- Fujiki, Y., M. Onodera, T. Yamaguchi, M. Osawa, K. Sudo, H. Hamada, H. Ema, A. Shibuya, M. Takiguchi, T. Kubo, and H. Nakauchi, Dominant expansion of human T cells in non-obese diabetic/severe combined immunodeficiency mice implanted with human bone fragments. Exp Hematol, 2000. 28(7): p. 792-801.
- Yamazaki, Y., R. Sanokawa, Y. Fujita, D. Zhou, K. Kawasaki, H. Tanaka, T. Komatsu, T. Nagasawa, and S. Oka, Cytoplasmic elongation and rupture in megakaryoblastic leukemia cells via activation of adhesion and motility by staurosporine on fibronectin-bound substratum. J Cell Physiol, 1999. 179(2): p. 179-92.
- Urasaki, T., H. Ninomiya, J. Takasaki, Y. Kawauchi, T. Nagasawa, and Y. Masuho, Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. Inflamm Res, 1999. 48(1): p. 36-40.
- Tanaka, R., K. Fujimori, N. Itoh, N. Okada, T. Nakamura, T. Sooma, H. Yokoi, S. Imagawa, M. Hareyama, and K. Fujita, [Correlation of risk area and reverse redistribution of 99mTc-sestamibi SPECT in acute myocardial infarction following direct PTCA]. Kaku Igaku, 1999. 36(3): p. 229-36.
- Suzukawa, K., T. Kodera, S. Shimizu, T. Nagasawa, H. Asou, N. Kamada, M. Taniwaki, J. Yokota, and K. Morishita, Activation of EVI1 transcripts with chromosomal translocation joining the TCRVbeta locus and the EVI1 gene in human acute undifferentiated leukemia cell line (Kasumi-3) with a complex translocation of der(3)t(3;7;8). Leukemia, 1999. 13(9): p. 1359-66.
- Shigeta, O., H. Kojima, Y. Hiramatsu, T. Jikuya, Y. Terada, N. Atsumi, Y. Sakakibara, T. Nagasawa, and T. Mitsui, Low-dose protamine based on heparin-protamine titration method reduces platelet dysfunction after cardiopulmonary bypass. J Thorac Cardiovasc Surg, 1999. 118(2): p. 354-60.
- Osada, M., T. Komeno, K. Todokoro, M. Takizawa, H. Kojima, K. Suzukawa, H. Ninomiya, T. Abe, and T. Nagasawa, Immature megakaryocytes undergo apoptosis in the absence of thrombopoietin. Exp Hematol, 1999. 27(1): p. 131-8.
- Ohkoshi, Y., H. Ninomiya, H.Y. Mukai, N. Mochizuki, M. Hori, T. Nagasawa, T. Jikuya, and Y. Saida, Pseudoaneurysm of the subclavian artery due to Xanthomonas pneumonia in a patient with acute myeloid leukemia: its rupture treated by transcatheter coil embolization. Intern Med, 1999. 38(8): p. 671-4.
- Obara, N., Y. Ohkoshi, H.Y. Mukai, T. Komeno, Y. Hasegawa, H. Kojima, H. Ninomiya, and T. Nagasawa, [T-cell prolymphocytic leukemia with CD4+8+25+ phenotype in a patient presenting with venous thrombosis in the lower leg]. Rinsho Ketsueki, 1999. 40(11): p. 1187-92.
- Ninomiya, H., Y. Kawashima, Y. Hasegawa, and T. Nagasawa, Complement-induced procoagulant alteration of red blood cell membranes with microvesicle formation in paroxysmal nocturnal haemoglobinuria (PNH): implication for thrombogenesis in PNH. Br J Haematol, 1999. 106(1): p. 224-31.
- Mukai, H.Y., H. Kojima, K. Suzukawa, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, N. Mori, and T. Nagasawa, High-dose chemotherapy with peripheral blood stem cell rescue in blastoid natural killer cell lymphoma. Leuk Lymphoma, 1999. 32(5-6): p. 583-8.
- Matsumoto, Y., M. Mori, N. Kanai, T. Izumi, M. Takatoku, K. Muroi, S. Imagawa, N. Komatsu, K. Hatake, Y. Sakata, K. Saito, and K. Ozawa, [Systemic lupus erythematosus presenting as fulminant thrombotic thrombocytopenic purpura]. Rinsho Ketsueki, 1999. 40(8): p. 673-7.
- Ino, M., S. Nagase, T. Nagasawa, A. Koyama, and S. Tachibana, The outer membrane protein I of Pseudomonas aeruginosa PAO1, a possible pollutant of dialysate in hemodialysis, induces cytokines in mouse bone marrow cells. Nephron, 1999. 82(4): p. 324-30.
- Imagawa, S., [Erythropoietin and hypoxia responsive system]. Tanpakushitsu Kakusan Koso, 1999. 44(15 Suppl): p. 2478-84.
- Imagawa, S., [Erythropoietin gene regulation]. Seikagaku, 1999. 71(9): p. 1162-6.
- Hasegawa, Y., T. Itoh, Y. Tamagawa, T. Komeno, H. Kojima, H. Ninomiya, Y. Yatabe, N. Mori, and T. Nagasawa, Non-Hodgkin's lymphoma followed by plasmacytoma, both arising in A thyroid gland with Hashimoto's disease. Leuk Lymphoma, 1999. 35(5-6): p. 613-8.
- Bai, A., H. Kojima, M. Hori, N. Nara, T. Komeno, Y. Hasegawa, H. Ninomiya, T. Abe, and T. Nagasawa, Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells. Exp Hematol, 1999. 27(2): p. 259-65.
- Takahashi, S., T. Komeno, N. Suwabe, K. Yoh, O. Nakajima, S. Nishimura, T. Kuroha, T. Nagasawa, and M. Yamamoto, Role of GATA-1 in proliferation and differentiation of definitive erythroid and megakaryocytic cells in vivo. Blood, 1998. 92(2): p. 434-42.
- Tabata, M., M. Yoshida, T. Izumi, C. Kawano, R. Kuribara, M. Toshima, K. Omine, M. Takatoku, M. Uchida, K. Kirito, A. Miyazato, H. Takahashi, M. Hoshino, Y. Terui, H. Tomizuka, T. Otsuki, R. Shimizu, J. Tsunoda, K. Muroi, Y. Furukawa, Y. Amemiya, S. Imagawa, N. Komatsu, T. Suzuki, Y. Miura, and et al., [Retrospective analysis of elderly patients > or = 60 years of age with acute leukemia]. Rinsho Ketsueki, 1998. 39(3): p. 176-84.
- Suzukawa, K., H. Kojima, and T. Nagasawa, [Anaplastic large cell lymphoma]. Ryoikibetsu Shokogun Shirizu, 1998(22 Pt 3): p. 298-300.
- Suzukawa, K., H. Kojima, N. Mori, H.Y. Mukai, M. Hori, T. Komeno, Y. Hasegawa, H. Ninomiya, and T. Nagasawa, Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement. Ann Hematol, 1998. 77(6): p. 287-90.
- Nagasawa, T., Y. Hasegawa, S. Shimizu, Y. Kawashima, S. Nishimura, K. Suzukawa, H. Mukai, M. Hori, T. Komeno, H. Kojima, H. Ninomiya, T. Tahara, and T. Abe, Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects. Br J Haematol, 1998. 101(2): p. 242-4.
- Nagasawa, T., [Amegakaryocytic thrombocytopenia]. Ryoikibetsu Shokogun Shirizu, 1998(21 Pt 2): p. 342-6.
- Kuroha, T., S. Takahashi, T. Komeno, K. Itoh, T. Nagasawa, and M. Yamamoto, Ablation of Nrf2 function does not increase the erythroid or megakaryocytic cell lineage dysfunction caused by p45 NF-E2 gene disruption. J Biochem (Tokyo), 1998. 123(3): p. 376-9.
- Hori, M. and T. Nagasawa, [Intravascular lymphoma (IVL)]. Ryoikibetsu Shokogun Shirizu, 1998(22 Pt 3): p. 294-7. 96. Hasegawa, Y. and T. Nagasawa, [Thrombocytopenia and neutropenia]. Ryoikibetsu Shokogun Shirizu, 1998(21 Pt 2): p. 329-31.
- Hamazaki, Y., H. Kojima, H. Mano, Y. Nagata, K. Todokoro, T. Abe, and T. Nagasawa, Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. Oncogene, 1998. 16(21): p. 2773-9.
- Abe, F., M. Hirokawa, T. Yamauchi, K. Honda, N. Hayashi, M. Ishii, S. Imagawa, and M. Iwahana, Further investigation of phenanthroindolizidine alkaloids from Tylophora tanakae. Chem Pharm Bull (Tokyo), 1998. 46(5): p. 767-9.
- Suzukawa, K., T. Taki, T. Abe, H. Asoh, N. Kamada, J. Yokota, and K. Morishita, Identification of translocational breakpoints within the intron region before the last coding exon (exon 12) of the EVI1 gene in two cases of CML-BC with inv(3)(q21q26). Genomics, 1997. 42(2): p. 356-60.
- Shinagawa, A., T. Itoh, T. Komeno, T. Komatsu, Y. Hasegawa, T. Kobayashi, H. Kozima, H. Ninomiya, T. Nagasawa, and T. Abe, [Allopurinol induced pancytopenia in a patient with myeloproliferative disorder]. Rinsho Ketsueki, 1997. 38(1): p. 64-71.
- Shigeta, O., H. Kojima, T. Jikuya, Y. Terada, N. Atsumi, Y. Sakakibara, T. Nagasawa, and T. Mitsui, Aprotinin inhibits plasmin-induced platelet activation during cardiopulmonary bypass. Circulation, 1997. 96(2): p. 569-74.
- Ninomiya, H., Y. Hasegawa, T. Nagasawa, and T. Abe, Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity. Int J Hematol, 1997. 65(3): p. 285-91.
- Nagata, Y., Y. Shozaki, H. Nagahisa, T. Nagasawa, T. Abe, and K. Todokoro, Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thromb Haemost, 1997. 77(5): p. 808-14.
- Mukai, H.Y., H. Ninomiya, T. Nagasawa, and T. Abe, Elevated serum levels of eosinophil major basic protein in patients with myeloproliferative disorders without eosinophilia. Int J Hematol, 1997. 66(2): p. 197-202.
- Imagawa, S., M. Yamamoto, and Y. Miura, Negative regulation of the erythropoietin gene expression by the GATA transcription factors. Blood, 1997. 89(4): p. 1430-9.
- Hamaguchi, H., K. Suzukawa, K. Nagata, K. Yamamoto, F. Yagasaki, and K. Morishita, Establishment of a novel human myeloid leukaemia cell line (HNT-34) with t(3;3)(q21;q26), t(9;22)(q34;q11) and the expression of EVI1 gene, P210 and P190 BCR/ABL chimaeric transcripts from a patient with AML after MDS with 3q21q26 syndrome. Br J Haematol, 1997. 98(2): p. 399-407.
- Taki, T., Y. Hayashi, M. Taniwaki, M. Seto, R. Ueda, R. Hanada, K. Suzukawa, J. Yokota, and K. Morishita, Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. Oncogene, 1996. 13(10): p. 2121-30.
- Nagahisa, H., Y. Nagata, T. Ohnuki, M. Osada, T. Nagasawa, T. Abe, and K. Todokoro, Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood, 1996. 87(4): p. 1309-16.
- Mukai, H.Y., H. Kojima, K. Todokoro, T. Tahara, T. Kato, Y. Hasegawa, T. Kobayashi, H. Ninomiya, T. Nagasawa, and T. Abe, Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thromb Haemost, 1996. 76(5): p. 675-8.
- Komeno, T., T. Itoh, K. Ohtani, M. Kamoshita, Y. Hasegawa, M. Hori, T. Kobayashi, T. Nagasawa, and T. Abe, Disseminated nontuberculous mycobacteriosis caused by mycobacterium kansasii in a patient with myelodysplastic syndrome. Intern Med, 1996. 35(4): p. 323-6.
- Komeno, T., K. Ohtani, Y. Hasegawa, A. Shinagawa, H. Mukai, T. Komatsu, T. Nagasawa, and T. Abe, [Appearance of cytoplasmic processes of megakaryocytes in the peripheral blood in a Munchausen syndrome with factitious anemia]. Rinsho Ketsueki, 1996. 37(9): p. 848-52.
- Kobayashi, T., T. Nagasawa, S. Mitsuhashi, Y. Hasegawa, H. Kojima, H. Ninomiya, N. Mori, and T. Abe, Clinicopathological characteristics of primary Ki-1 anaplastic large cell lymphoma. Int J Hematol, 1996. 63(1): p. 41-50.
- Izumi, T., T. Ohtsuki, K. Ohya, Y. Ogawa, M. Yoshida, K. Muroi, S. Imagawa, K. Hatake, K. Kuriki, K. Saito, and Y. Miura, Therapy-related leukemia with a novel 21q22 rearrangement. Cancer Genet Cytogenet, 1996. 90(1): p. 45-8.
- Izumi, T., S. Imagawa, K. Hatake, Y. Miura, T. Ariyama, J. Inazawa, and T. Abe, Philadelphia chromosome-negative cells with trisomy 8 after busulfan and interferon treatment of Ph1-positive chronic myelogenous leukemia. Int J Hematol, 1996. 64(1): p. 73-7.
- Izumi, T., S. Imagawa, K. Muroi, R. Shimizu, H. Takahashi, Y. Hoshino, H. Tomizuka, T. Kawakami, K. Toya, H. Kurata, J. Tsunoda, Y. Furukawa, T. Suzuki, N. Komatsu, A. Ohsaka, Y. Amemiya, S. Takagi, M. Yoshida, R. Sasaki, K. Hatake, and Y. Miura, [Retrospective analysis on 21 patients with follicular lymphoma]. Rinsho Ketsueki, 1996. 37(1): p. 7-13.
- Ito, T., H. Kojima, K. Otani, T. Komeno, S. Mitsuhashi, Y. Hasegawa, T. Kobayashi, H. Ninomiya, T. Nagasawa, and T. Abe, Chronic neutrophilic leukemia associated with monoclonal gammopathy of undetermined significance. Acta Haematol, 1996. 95(2): p. 140-3.
- Imagawa, S., M. Yamamoto, M. Ueda, and Y. Miura, Erythropoietin gene expression by hydrogen peroxide. Int J Hematol, 1996. 64(3-4): p. 189-95.
- Imagawa, S., M. Yamamoto, and Y. Miura, GATA transcription factors negatively regulate erythropoietin gene expression. Acta Haematol, 1996. 95(3-4): p. 248-56.
- Hagiwara, T., T. Nagasawa, H. Nagahisa, M. Takizawa, M. Osada, and T. Abe, Expression of adhesion molecules on cytoplasmic processes of human megakaryocytes. Exp Hematol, 1996. 24(6): p. 690-5.
- Asou, H., K. Suzukawa, K. Kita, K. Nakase, H. Ueda, K. Morishita, and N. Kamada, Establishment of an undifferentiated leukemia cell line (Kasumi-3) with t(3;7)(q27;q22) and activation of the EVI1 gene. Jpn J Cancer Res, 1996. 87(3): p. 269-74.
- Asou, H., M. Eguchi, K. Suzukawa, K. Morishita, K. Tanaka, M. Date, K. Hamamoto, and N. Kamada, Establishment of a myeloid leukaemia cell line (Kasumi-4) with t(9;22;11)(q34;q11;q13), inv(3)(q21q26) and the EVI1 gene activation from a patient with chronic myelogenous leukaemia in blast crisis. Br J Haematol, 1996. 93(1): p. 68-74.
- Suzukawa, K., H. Satoh, M. Taniwaki, J. Yokota, and K. Morishita, The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q21q26 syndrome). Leukemia, 1995. 9(8): p. 1328-31.
- Ohtani, K., H. Ninomiya, Y. Hasegawa, T. Kobayashi, H. Kojima, T. Nagasawa, and T. Abe, Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Br J Haematol, 1995. 91(1): p. 116-20.
- Nagasawa, T., Y. Hasegawa, T. Komeno, T. Itoh, H. Ninomiya, and T. Abe, Simultaneous measurements of megakaryocyte-associated IgG (MAIgG) and platelet-associated IgG (PAIgG) in chronic idiopathic thrombocytopenic purpura. Eur J Haematol, 1995. 54(5): p. 314-20.
- Nagasawa, T., Y. Hasegawa, M. Kamoshita, K. Ohtani, T. Komeno, T. Itoh, A. Shinagawa, H. Kojima, H. Ninomiya, and T. Abe, Megakaryopoiesis in patients with cyclic thrombocytopenia. Br J Haematol, 1995. 91(1): p. 185-90.
- Muroi, K., S. Imagawa, T. Suzuki, Y. Amemiya, and Y. Miura, B-cell lymphoma terminating in acute monoblastic leukemia. Intern Med, 1995. 34(1): p. 36-8.
- Mukai, H.Y., H. Ninomiya, K. Ohtani, T. Nagasawa, and T. Abe, Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Br J Haematol, 1995. 90(4): p. 892-9.
- Morishita, K., K. Suzukawa, T. Taki, J.N. Ihle, and J. Yokota, EVI-1 zinc finger protein works as a transcriptional activator via binding to a consensus sequence of GACAAGATAAGATAAN1-28 CTCATCTTC. Oncogene, 1995. 10(10): p. 1961-7.
- Mitsuhashi, S., T. Nagasawa, M. Kamoshita, K. Otani, Y. Hasegawa, H. Kojima, H. Ninomiya, M. Nakazawa, and T. Abe, [Minimally differentiated hypoplastic leukemia]. Rinsho Ketsueki, 1995. 36(2): p. 115-20.
- Kojima, H., Y. Hamazaki, Y. Nagata, K. Todokoro, T. Nagasawa, and T. Abe, Modulation of platelet activation in vitro by thrombopoietin. Thromb Haemost, 1995. 74(6): p. 1541-5.
- Kamoshita, M., K. Suzukawa, T. Kobayashi, Y. Hasegawa, Y. Satoh, H. Ninomiya, T. Nagasawa, and T. Abe, [von Recklinghausen's disease complicated by macroglobulinemia, malignant schwannoma and pheochromocytoma]. Rinsho Ketsueki, 1995. 36(1): p. 59-62.
- Hasegawa, Y., T. Nagasawa, M. Kamoshita, T. Komeno, T. Itoh, H. Ninomiya, and T. Abe, Effects of anti-platelet glycoprotein Ib and/or IIb/IIIa autoantibodies on the size of megakaryocytes in patients with immune thrombocytopenia. Eur J Haematol, 1995. 55(3): p. 152-7.
- Hagiwara, S., A. Miwa, M. Yoshida, S. Imagawa, N. Komatu, K. Muroi, R. Sasaki, K. Hatake, S. Sakamoto, and S. Miura, Methicillin-resistant Staphylococcus aureus: colonization and development of infection in patients with haematological disorders. Eur J Haematol, 1995. 55(4): p. 267-71.
- Suzukawa, K., E. Parganas, A. Gajjar, T. Abe, S. Takahashi, K. Tani, S. Asano, H. Asou, N. Kamada, J. Yokota, and et al., Identification of a breakpoint cluster region 3' of the ribophorin I gene at 3q21 associated with the transcriptional activation of the EVI1 gene in acute myelogenous leukemias with inv(3)(q21q26). Blood, 1994. 84(8): p. 2681-8.
- Okano, M., S. Masuda, H. Narita, S. Masushige, S. Kato, S. Imagawa, and R. Sasaki, Retinoic acid up-regulates erythropoietin production in hepatoma cells and in vitamin A-depleted rats. FEBS Lett, 1994. 349(2): p. 229-33.
- Ohyashiki, K., J.H. Ohyashiki, H. Fujieda, T. Shimamoto, K. Kawakubo, S. Nakazawa, K. Suzukawa, K. Morishita, and K. Toyama, EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. Leukemia, 1994. 8(12): p. 2169-73.
- Kojima, H., K. Suzukawa, Y. Yatabe, M. Hori, T. Nagasawa, and T. Abe, Establishment of a new natural killer (NK) cell line, TKS-1, from a patient with aggressive type of large granular lymphocyte (LGL) leukemia. Leukemia, 1994. 8(11): p. 1999-2004.
- Izumi, T., K. Muroi, M. Takatoku, S. Imagawa, K. Hatake, and Y. Miura, Development of acute myeloblastic leukaemia in a case of aplastic anaemia treated with granulocyte colony-stimulating factor. Br J Haematol, 1994. 87(3): p. 666-8.
- Izumi, T., K. Hatake, S. Imagawa, M. Yoshikda, M. Ohta, R. Sasaki, A. Miwa, T. Suda, S. Sakamoto, and Y. Miura, [A case of acute promyelocytic leukemia (APL) with myeloblastoma in the oral cavity developing after receiving all-trans retinoic acid (ATRA)]. Rinsho Ketsueki, 1994. 35(6): p. 598-602.
- Imagawa, S., T. Izumi, and Y. Miura, Positive and negative regulation of the erythropoietin gene. J Biol Chem, 1994. 269(12): p. 9038-44.
- Hoshi, M., T. Nagasawa, T. Abe, T. Satoh, and Y. Mitsui, Maturation of human megakaryocytic cell line (CMK-7) on the human umbilical vein endothelial cell (EC) monolayer. Int J Hematol, 1994. 59(3): p. 191-9.
- Hori, M., S. Mitsuhashi, T. Kobayashi, T. Nagasawa, N. Mori, M. Miwa, and T. Abe, CD30-positive lymphoma in human T-cell leukaemia virus type 1 carrier without monoclonal integration of HTLV-1. Br J Haematol, 1994. 88(2): p. 419-20.
- Yoshida, M., H. Kurata, S. Tsunoda, A. Iwama, T. Suzuki, M. Akutsu, S. Imagawa, J. Tsunoda, Y. Furukawa, N. Komatsu, and et al., [Treatment of 71 adult acute lymphoblastic leukemia]. Gan To Kagaku Ryoho, 1993. 20(12): p. 1827-33.
- Suzukawa, K., H. Ninomiya, S. Mitsuhashi, I. Anno, T. Nagasawa, and T. Abe, Demonstration of the deposition of hemosiderin in the kidneys of patients with paroxysmal nocturnal hemoglobinuria by magnetic resonance imaging. Intern Med, 1993. 32(9): p. 686-90.
- Sato, Y., S. Mituhashi, K. Otani, M. Kamoshita, Y. Hasegawa, H. Ninomiya, T. Nagasawa, and T. Abe, [A study of hypoplastic myelodysplastic syndrome]. Rinsho Ketsueki, 1993. 34(11): p. 1431-7.
- Ninomiya, H., Y. Muraki, K. Shibuya, T. Nagasawa, and T. Abe, Induction of Fc gamma R-III (CD16) expression on neutrophils affected by paroxysmal nocturnal haemoglobinuria by administration of granulocyte colony-stimulating factor. Br J Haematol, 1993. 84(3): p. 497-503.
- Nagasawa, T., [Megakaryopoiesis in chronic myeloproliferative disorders]. Rinsho Ketsueki, 1993. 34(5): p. 551-6.
- Nagasawa, T., H. Yanagisawa, Y. Hasegawa, H. Kanma, and T. Abe, Polycythemia associated with primary systemic amyloidosis: elevated levels of hemopoietic factors and cytokines. Am J Hematol, 1993. 43(1): p. 57-60.
- Kojima, H., M. Hori, A. Shibuya, T. Nagasawa, M. Miwa, and T. Abe, Successful treatment of a patient with adult T-cell leukemia by daily oral administration of low-dose etoposide. Decrease in the amount of HTLV-I proviral DNA revealed by the polymerase chain reaction method. Cancer, 1993. 72(12): p. 3614-7
- Kamoshita, M., K. Ohtani, Y. Hasegawa, Y. Satoh, H. Kozima, A. Shibuya, H. Ninomiya, T. Nagasawa, Y. Matsunaga, and T. Abe, [Human parvovirus B19-induced aplastic crisis in an elderly man with intestinal hemorrhage]. Rinsho Ketsueki, 1993. 34(4): p. 493-5.
- Hatake, K., T. Izumi, S. Imagawa, M. Ohta, and Y. Miura, Macrophage colony-stimulating factor and platelet recovery after chemotherapy. Lancet, 1993. 341(8850): p. 963.
- Hasegawa, Y., T. Nagasawa, H. Kojima, A. Shibuya, H. Ninomiya, and T. Abe, [Treatment of elderly patients with chronic idiopathic thrombocytopenic purpura]. Rinsho Ketsueki, 1993. 34(4): p. 460-4.
- Tsunoda, S., M. Yoshida, S. Takagi, R. Sasaki, K. Muroi, M. Hoshino, T. Izumi, S. Imagawa, H. Ema, T. Suzuki, and et al., [Acute undifferentiated leukemia from the viewpoints of diagnosis and therapy]. Rinsho Ketsueki, 1992. 33(9): p. 1136-43.
- Shibuya, A., Y. Muraki, Y. Satoh, T. Kobayashi, H. Kojima, T. Nagasawa, T. Abe, J. Tomiyama, H. Kudoh, Y. Adachi, and et al., [Clinicopathological study of 6 cases of mantle zone lymphoma]. Rinsho Ketsueki, 1992. 33(6): p. 770-5.
- Muraki, Y., T. Kobayashi, H. Kojima, A. Shibuya, T. Nagasawa, T. Abe, and N. Mori, [Anorexia nervosa with neutropenia--response of neutrophils to G-CSF]. Rinsho Ketsueki, 1992. 33(3): p. 328-32.
- Kobayashi, T., Y. Sato, Y. Hasegawa, T. Nagasawa, Y. Yoda, and T. Abe, Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon. Intern Med, 1992. 31(7): p. 936-40.
- Fukunaga, N., S. Imagawa, T. Sahara, A. Ishii, and M. Suzuki, Purification and characterization of monomeric isocitrate dehydrogenase with NADP(+)-specificity from Vibrio parahaemolyticus Y-4. J Biochem (Tokyo), 1992. 112(6): p. 849-55.
- Yanagisawa, H., T. Nagasawa, S. Kuramochi, T. Abe, Y. Ikawa, and K. Todokoro, Constitutive expression of exogenous c-myb gene causes maturation block in monocyte-macrophage differentiation. Biochim Biophys Acta, 1991. 1088(3): p. 380-4.
- Todokoro, K., S. Kuramochi, T. Nagasawa, T. Abe, and Y. Ikawa, Isolation of a cDNA encoding a potential soluble receptor for human erythropoietin. Gene, 1991. 106(2): p. 283-4.
- Natsuda, H., Y. Muraki, T. Kobayashi, H. Kozima, A. Shibuya, T. Nagasawa, and T. Abe, [Adult T cell lymphoma/leukemia with alopecia, huge tumors of scalp and wide destruction of cerebral bone]. Rinsho Ketsueki, 1991. 32(5): p. 537-41.
- Nagasawa, T., K. Satoh, and T. Abe, Thrombopoietic factor enhances murine megakaryopoiesis induced by recombinant erythropoietin. Int J Hematol, 1991. 54(2): p. 159-64.
- Muroi, K., S. Imagawa, T. Suda, E. Kajii, Y. Otuka, I. Sakurabayashi, Y. Amemiya, S. Sakamoto, and Y. Miura, [Multiple myeloma with hemolytic anemia and thrombocytopenia]. Rinsho Ketsueki, 1991. 32(8): p. 909-11.
- Itoh, M., M. Yoshida, H. Kurata, S. Imagawa, M. Hoshino, J. Tsunoda, H. Ema, S. Tsunoda, T. Suzuki, N. Komatsu, and et al., [Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis]. Rinsho Ketsueki, 1991. 32(2): p. 115-20.
- Imagawa, S., M.A. Goldberg, J. Doweiko, and H.F. Bunn, Regulatory elements of the erythropoietin gene. Blood, 1991. 77(2): p. 278-85.
- Goldberg, M.A., S. Imagawa, R.K. Strair, and H.F. Bunn, Regulation of the erythropoietin gene in Hep 3B cells. Semin Hematol, 1991. 28(3 Suppl 3): p. 35-40; discussion 40-1.
- Ema, H., T. Suda, H. Nakauchi, Y. Nakamura, A. Iwama, S. Imagawa, M. Akutsu, Y. Kano, S. Kato, M. Yabe, and et al., Multipotent and committed CD34+ cells in bone marrow transplantation. Jpn J Cancer Res, 1991. 82(5): p. 547-52.
- Satoh, K., T. Nagasawa, and T. Abe, Simultaneous assay for megakaryocyte colony-stimulating factor and megakaryocyte potentiator and its application. J Lab Clin Med, 1990. 116(2): p. 162-71.
- Nagasawa, T., T. Orita, J. Matsushita, M. Tsuchiya, T. Neichi, I. Imazeki, N. Imai, N. Ochi, H. Kanma, and T. Abe, Thrombopoietic activity of human interleukin-6. FEBS Lett, 1990. 260(2): p. 176-8.
- Nagasawa, T., T. Kobayashi, Y. Satoh, H. Yanagisawa, M. Nakazawa, and T. Abe, [The relationship between responsiveness to splenectomy and clinical course after splenectomy in chronic idiopathic thrombocytopenic purpura (ITP)]. Rinsho Ketsueki, 1990. 31(7): p. 922-8.
- Kojima, H., Y. Hasegawa, T. Ikegami, T. Nagasawa, and T. Abe, [Chronic myelogenous leukemia with marked thrombocytosis--comparison with essential thrombocythemia with Ph1 in its megakaryokinetics]. Rinsho Ketsueki, 1990. 31(1): p. 35-40.
- Hanada, T., I. Ono, and T. Nagasawa, Childhood cyclic neutropenia treated with recombinant human granulocyte colony stimulating factor. Br J Haematol, 1990. 75(1): p. 135-7.
- Tomiyama, J., Y. Hasegawa, T. Nagasawa, T. Abe, H. Horiguchi, and T. Ogata, Bacillus cereus septicemia associated with rhabdomyolysis and myoglobinuric renal failure. Jpn J Med, 1989. 28(2): p. 247-50.
- Imagawa, S., M.A. Goldberg, and H.F. Bunn, Regulation of the erythropoietin gene. Adv Exp Med Biol, 1989. 271: p. 75-85.
- Imagawa, S., B.R. Smith, R. Palmer-Crocker, and H.F. Bunn, The effect of recombinant erythropoietin on intracellular free calcium in erythropoietin-responsive cells. Blood, 1989. 73(6): p. 1452-7.
- Goldberg, M.A., S. Imagawa, P.S. Dunning, and H.F. Bunn, Oxygen sensing and erythropoietin gene regulation. Contrib Nephrol, 1989. 76: p. 39-54; discussion 54-6
- Shibuya, A., H. Ninomiya, M. Nakazawa, T. Nagasawa, Y. Yoda, and T. Abe, Oxymetholone therapy in patients with familial antithrombin III deficiency. Thromb Haemost, 1988. 60(3): p. 495-7.
- Ninomiya, H., J. Tomiyama, S. Imagawa, A. Shibuya, T. Hanada, T. Kageoka, T. Nagasawa, Y. Yoda, T. Abe, and T. Fujita, [Recurrence of thromboses and infections in a patient with paroxysmal nocturnal hemoglobinuria (PNH)]. Rinsho Ketsueki, 1988. 29(1): p. 54-8.
- Nagasawa, T., T. Neichi, K. Satoh, M. Nakazawa, and T. Abe, In vitro regulatory mechanisms for cytoplasmic maturation of murine megakaryocytes derived from colony-forming units megakaryocyte (CFU-M). Exp Hematol, 1988. 16(8): p. 667-73.
- Hanada, T., K. Koike, T. Takeya, T. Nagasawa, Y. Matsunaga, and H. Takita, Human parvovirus B19-induced transient pancytopenia in a child with hereditary spherocytosis. Br J Haematol, 1988. 70(1): p. 113-5.
- Hanada, T., K. Saito, T. Nagasawa, T. Kabashima, S. Nakahara, A. Okuyama, and H. Takita, Intravenous gammaglobulin therapy for thromboneutropenic neonates of mothers with systemic lupus erythematosus. Eur J Haematol, 1987. 38(5): p. 400-4.
造血幹細胞移植チーム
造血幹細胞移植では，血液の病気そのものの制御だけではなく，感染症や移植片対宿主病（GVHD）などの合併症の管理や，社会的・心理的なサポートが，治療成功の鍵を握ります．そのため血液内科医の他に，高い専門性を持った他職種の協力が欠かせません．当科では，様々な職種がそれぞれ対等の立場で，移植を受けた患者さんの治療やケアに協働して関わっています． 2012年末から稼働した新病棟「けやき棟」では，同種造血幹細胞移植を行うことができる病床が6床に増えました．それに伴い，「造血幹細胞移植チーム」が新たな形で発足しています．血液内科医，看護師，リハビリ医，理学療法士，薬剤師，臨床心理士，歯科衛生士，移植コーディネータ等，多種多様な職種がチームを形成し，治療やケアへの積極的な介入，病棟カンファレンス（週1回）や研修会などを開催しています．
多職種が集まる
病棟カンファレンス
移植リハビリテーションに
関する研修会
専門領域
- 千葉 滋（造血幹細胞移植、造血器腫瘍、再生不良性貧血）a,c,d,e,g
- 小原 直（再生不良性貧血、造血器腫瘍）a,c,f
- 坂田 麻実子（造血器腫瘍）a,b,c,d
- 錦井 秀和（血小板疾患、造血幹細胞移植）a,c,d,f
- 横山 泰久（造血幹細胞移植、造血器腫瘍）a,b,c,g
- 栗田 尚樹（造血幹細胞移植）a,b,c,g
- 加藤 貴康（造血器腫瘍）a,c
- 坂本 竜弘（再生不良性貧血、骨髄異形成症候群）a,c
b: 日本内科学会専門医
c: 日本血液学会専門医
d: 日本血液学会指導医
e: 日本臨床腫瘍学会暫定指導医
f: 日本輸血・細胞治療学会認定医
g: 日本造血幹細胞移植学会認定医
治療分野
私たち血液内科診療グループでは、白血病・リンパ腫・多発性骨髄腫などの造血器腫瘍、再生不良性貧血等の造血障害を呈する疾患、鉄欠乏症・ビタミンB12欠乏症、葉酸欠乏症、各種液性貧血、スポーツ貧血などの貧血、特発性血小板減少性紫斑病・自己免疫性溶血性貧血などの自己免疫疾患、血友病などの凝固障害、血栓性疾患などの患者さまを診療しております。また、これらの様々な疾患に対し、多数の造血幹細胞移植を行っております。
外来は原則として紹介状の持参が望ましく、月曜日から金曜日の午前中に受け付ております。血液疾患の特性上、急を要する患者さまは直接御連絡いただければ、外来日以外でも受診可能です。
入院中の方の診療は、血液診療グループの指導のもとで、血液専門の指導医（主治医）、副主治医、受持医が治療にあたりますが、治療方針を頻繁に協議し合いチーム医療を行っております。患者さまには、治療に際して出来るだけ病状を詳細に説明し、治療方針を御理解いただき、患者さまと共通の理解のもとで加療するようにしております。退院された後も不具合がありましたら、出来るだけ速やかに診療できるよう努力しております。
患者さんへ
こちらは、診察を受けた医師から「血液内科」を受診するように言われた方、すでに血液の病気で治療を受けている方、血液の病気に興味をお持ちの方、などのためのページです。
筑波大学附属病院・血液内科診療グループでは、血液の病気にお困りの患者さんに対し、最善の治療を行うことができるよう、多数の血液内科専門医・血液内科指導医が診療にあたっております。
血液の病気には、(1)腫瘍性の病気：白血病、悪性リンパ腫、多発性骨髄腫、骨髄増殖性疾患、骨髄異形成症候群の一部など（詳細はがん対策情報センターの「その他のがんの解説」をご覧下さい）、(2)赤血球・白血球・血小板の異常：骨髄異形成症候群の一部、再生不良性貧血、溶血性貧血、血小板減少性紫斑病など、(3)血液凝固因子の異常：血友病など、が含まれます（詳細は日本血栓止血学会の「用語集」をご覧下さい）。これらの病気の中には、治療が難しく、治りにくい病気も含まれています。抗がん剤を用いて治療を行う場合も多く、また骨髄移植（あるいは末梢血幹細胞移植や臍帯血移植）といった治療が必要になる患者さんもいらっしゃいます。しかしながら、医学は今、めざましい勢いで進歩しております。わたしたちの血液内科領域は、その中でも速く進歩している分野です。数年前まではなかなか治らなかった病気が治るようになり、ついこの間まで移植が必要であった病気が、飲み薬で治療できるようになりました。治療の選択肢もどんどん広がっています。わたしたちは、日々知識を改め、技術を磨き、常に最良で最先端の治療を行うことができるよう、準備を整えています。
しかし、どの治療法がもっとも良いか（標準的治療法）がはっきりしない場合も少なくありません。このような場合には、方法や倫理的側面について厳密に審査を受けた上で、新しく開発されつつある治療法を試したり、いくつかの方法を比べたりする臨床試験を行うことを、患者さんに提案する場合もあります。なお、筑波大学附属病院・血液内科診療グループは、日本血液学会が認定する日本血液学会研修施設です。したがって、初期研修を終え、さらに内科全般のトレーニングも修了し、血液内科専門のトレーニングを行うために、後期研修医も血液内科専門医・血液内科指導医であるスタッフの指導のもと、チームを作って診療に加わっています。チームは、スタッフ（主治医）、チーフレジデント、シニアレジデント、内科研修医、初期研修医などのうち数名で構成されており、現在は２チームで診療体制を作っています。平日は毎朝、まず全員で集合して当日の診療内容を確認し、その後各チームに分かれて入院患者さんを回診します。また定期的に、教授を含む全員で、患者さんごとに最良であると思われる治療法や、それに代わる治療法があるかを話し合い、患者さんやご家族に説明しながら診療を進めます。どのような場合であっても、患者さん個々の事情や状況を十分に理解した上で、どなたでも安心して治療が受けられるよう、私たちは良心に従い、最善を尽くすことをいつも忘れずに診療にあたります。
筑波大学附属病院・血液内科診療グループでは、血液の病気にお困りの患者さんに対し、最善の治療を行うことができるよう、多数の血液内科専門医・血液内科指導医が診療にあたっております。
血液の病気には、(1)腫瘍性の病気：白血病、悪性リンパ腫、多発性骨髄腫、骨髄増殖性疾患、骨髄異形成症候群の一部など（詳細はがん対策情報センターの「その他のがんの解説」をご覧下さい）、(2)赤血球・白血球・血小板の異常：骨髄異形成症候群の一部、再生不良性貧血、溶血性貧血、血小板減少性紫斑病など、(3)血液凝固因子の異常：血友病など、が含まれます（詳細は日本血栓止血学会の「用語集」をご覧下さい）。これらの病気の中には、治療が難しく、治りにくい病気も含まれています。抗がん剤を用いて治療を行う場合も多く、また骨髄移植（あるいは末梢血幹細胞移植や臍帯血移植）といった治療が必要になる患者さんもいらっしゃいます。しかしながら、医学は今、めざましい勢いで進歩しております。わたしたちの血液内科領域は、その中でも速く進歩している分野です。数年前まではなかなか治らなかった病気が治るようになり、ついこの間まで移植が必要であった病気が、飲み薬で治療できるようになりました。治療の選択肢もどんどん広がっています。わたしたちは、日々知識を改め、技術を磨き、常に最良で最先端の治療を行うことができるよう、準備を整えています。
しかし、どの治療法がもっとも良いか（標準的治療法）がはっきりしない場合も少なくありません。このような場合には、方法や倫理的側面について厳密に審査を受けた上で、新しく開発されつつある治療法を試したり、いくつかの方法を比べたりする臨床試験を行うことを、患者さんに提案する場合もあります。なお、筑波大学附属病院・血液内科診療グループは、日本血液学会が認定する日本血液学会研修施設です。したがって、初期研修を終え、さらに内科全般のトレーニングも修了し、血液内科専門のトレーニングを行うために、後期研修医も血液内科専門医・血液内科指導医であるスタッフの指導のもと、チームを作って診療に加わっています。チームは、スタッフ（主治医）、チーフレジデント、シニアレジデント、内科研修医、初期研修医などのうち数名で構成されており、現在は２チームで診療体制を作っています。平日は毎朝、まず全員で集合して当日の診療内容を確認し、その後各チームに分かれて入院患者さんを回診します。また定期的に、教授を含む全員で、患者さんごとに最良であると思われる治療法や、それに代わる治療法があるかを話し合い、患者さんやご家族に説明しながら診療を進めます。どのような場合であっても、患者さん個々の事情や状況を十分に理解した上で、どなたでも安心して治療が受けられるよう、私たちは良心に従い、最善を尽くすことをいつも忘れずに診療にあたります。
医療関係者の皆様へ
筑波大学附属病院血液内科は、1976年に筑波大学附属病院が開院して以来、積極的に白血病、悪性リンパ腫、多発性骨髄腫などの造血器腫瘍の治療に取り組んで参りました。また、再生不良性貧血と発作性夜間血色素尿症、および血小板系疾患や凝固異常症に対し、特色ある医療を展開して参りました。
一方、成人に対する同種造血幹細胞移植を茨城県内では最初に開始し、1998年から日本骨髄移植推進財団の認定施設として非血縁者間骨髄移植を、2000年から日本臍帯血バンクネットワークを介する臍帯血移植も開始しました（詳しくは治療成績のページをご参照ください）。この間、筑波大学卒業生を中心として県内の血液内科関連施設が名実ともに充実し、これらの施設と連携することで医療に携わる皆様のご支援を得ながら、県内・近隣諸県の住民を中心とした患者様に対する医療ニーズに対応して参りました。
直近1年の統計では、外来患者数は月間約1,100名、入院患者数は1日平均約45名（2008年3月～5月の実績は42～60名）です。今後も、これまでと同様の規模で診療を行って参ります。ただ、カバーすべき医療圏の人口を考えますと、造血幹細胞移植に関しては、まだ十分に責任を果たしているとはいえないと考えております。今後、造血幹細胞移植を含め、より高度な医療を積極的に展開して行きたいと思いますので、適切な患者様を積極的にご紹介いただければ幸いです。また、病診連携を進め、皆様のご協力を得ながら、患者様にご自宅や地域の施設にお帰りいただく環境を整えて参りたいと思います。医療関係者皆様に、ご理解とご支援を賜りますようお願い申し上げます。
外来は、診療内容のページの表に記載の通りに行っております。ご紹介いただく場合には、是非診療情報をご提供下さいますよう、よろしくお願い申し上げます。また、別途セカンド・オピニオン外来も行っております。セカンド・オピニオンをご希望される患者様がいらっしゃいましたら、専用窓口（電話：029-853-3560）にご連絡ください。
一方、成人に対する同種造血幹細胞移植を茨城県内では最初に開始し、1998年から日本骨髄移植推進財団の認定施設として非血縁者間骨髄移植を、2000年から日本臍帯血バンクネットワークを介する臍帯血移植も開始しました（詳しくは治療成績のページをご参照ください）。この間、筑波大学卒業生を中心として県内の血液内科関連施設が名実ともに充実し、これらの施設と連携することで医療に携わる皆様のご支援を得ながら、県内・近隣諸県の住民を中心とした患者様に対する医療ニーズに対応して参りました。
直近1年の統計では、外来患者数は月間約1,100名、入院患者数は1日平均約45名（2008年3月～5月の実績は42～60名）です。今後も、これまでと同様の規模で診療を行って参ります。ただ、カバーすべき医療圏の人口を考えますと、造血幹細胞移植に関しては、まだ十分に責任を果たしているとはいえないと考えております。今後、造血幹細胞移植を含め、より高度な医療を積極的に展開して行きたいと思いますので、適切な患者様を積極的にご紹介いただければ幸いです。また、病診連携を進め、皆様のご協力を得ながら、患者様にご自宅や地域の施設にお帰りいただく環境を整えて参りたいと思います。医療関係者皆様に、ご理解とご支援を賜りますようお願い申し上げます。
外来は、診療内容のページの表に記載の通りに行っております。ご紹介いただく場合には、是非診療情報をご提供下さいますよう、よろしくお願い申し上げます。また、別途セカンド・オピニオン外来も行っております。セカンド・オピニオンをご希望される患者様がいらっしゃいましたら、専用窓口（電話：029-853-3560）にご連絡ください。
血液内科の主な検査
血液内科独自の検査として、骨髄穿刺、骨髄生検いずれの検査も必要時適時施行しております。発作性夜間血色素尿症のフローサイトメトリーによる診断、白血病の遺伝子診断など、血液疾患の検査分野では院内で独自の検査態勢を整えております。
